Aims: Permanent treatment of morbid obesity with medication or diet is nearly impossible. Laparoscopic sleeve gastrectomy (LSG) is becoming a widely accepted treatment option. This study profiled and compared gut microbiota composition before and after LSG. Methods & results: A total of 54 stool samples were collected from 27 morbidly obese individuals before and after LSG. The gut microbiota was profiled with 16S amplicon sequencing. After LSG, patients demonstrated a significant decrease (p < 0.001) in BMI and an increase in bacterial diversity. An increased Firmicutes/Bacteroidetes ratio was also noticed after LSG. The families Prevotellaceae and Veillonellaceae predominated in preoperative samples but were markedly lowered after LSG. A marked increase in Akkermansia, Alistipes, Streptococcus, Ruminococcus and Parabacteroides was observed after LSG. Conclusion: In addition to lowering BMI, LSG remodeled gut microbiota composition.

Changes in the gut microbiota of morbidly obese patients after laparoscopic sleeve gastrectomy / Kural, A.; Khan, I.; Seyit, H.; Caglar, T. R.; Toklu, P.; Vural, M.. - In: FUTURE MICROBIOLOGY. - ISSN 1746-0913. - 17:1(2021), pp. 1-11. [10.2217/fmb-2021-0043]

Changes in the gut microbiota of morbidly obese patients after laparoscopic sleeve gastrectomy

Caglar T. R.;
2021

Abstract

Aims: Permanent treatment of morbid obesity with medication or diet is nearly impossible. Laparoscopic sleeve gastrectomy (LSG) is becoming a widely accepted treatment option. This study profiled and compared gut microbiota composition before and after LSG. Methods & results: A total of 54 stool samples were collected from 27 morbidly obese individuals before and after LSG. The gut microbiota was profiled with 16S amplicon sequencing. After LSG, patients demonstrated a significant decrease (p < 0.001) in BMI and an increase in bacterial diversity. An increased Firmicutes/Bacteroidetes ratio was also noticed after LSG. The families Prevotellaceae and Veillonellaceae predominated in preoperative samples but were markedly lowered after LSG. A marked increase in Akkermansia, Alistipes, Streptococcus, Ruminococcus and Parabacteroides was observed after LSG. Conclusion: In addition to lowering BMI, LSG remodeled gut microbiota composition.
2021
16s amplicon sequencing; gut microbiota; lsg; obesity; sleeve gastrectomy
01 Pubblicazione su rivista::01a Articolo in rivista
Changes in the gut microbiota of morbidly obese patients after laparoscopic sleeve gastrectomy / Kural, A.; Khan, I.; Seyit, H.; Caglar, T. R.; Toklu, P.; Vural, M.. - In: FUTURE MICROBIOLOGY. - ISSN 1746-0913. - 17:1(2021), pp. 1-11. [10.2217/fmb-2021-0043]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1614190
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