The COVID-19 pandemic has highlighted genetic vaccination as a powerful and cost-effective tool to counteract infectious diseases. Invasive fungal infections (IFI) remain a major challenge among immune compromised patients, particularly those undergoing allogeneic hematopoietic bone marrow transplantation (HSCT) or solid organ transplant (SOT) both presenting high morbidity and mortality rates. Candidiasis and Aspergillosis are the major fungal infections among these patients and the failure of current antifungal therapies call for new therapeutic aids. Vaccination represents a valid alternative, and proof of concept of the efficacy of this approach has been provided at clinical level. This review will analyze current understanding of antifungal immunology, with a particular focus on genetic vaccination as a suitable strategy to counteract these diseases.

Genetic Vaccination as a Flexible Tool to Overcome the Immunological Complexity of Invasive Fungal Infections / Luberto, L.; Neroni, B.; Gandini, O.; Fiscarelli, E. V.; Salvatori, G.; Roscilli, G.; Marra, E.. - In: FRONTIERS IN MICROBIOLOGY. - ISSN 1664-302X. - 12:Dec 15(2021), pp. 1-8. [10.3389/fmicb.2021.789774]

Genetic Vaccination as a Flexible Tool to Overcome the Immunological Complexity of Invasive Fungal Infections

Luberto L.
;
Neroni B.;Gandini O.;Roscilli G.;
2021

Abstract

The COVID-19 pandemic has highlighted genetic vaccination as a powerful and cost-effective tool to counteract infectious diseases. Invasive fungal infections (IFI) remain a major challenge among immune compromised patients, particularly those undergoing allogeneic hematopoietic bone marrow transplantation (HSCT) or solid organ transplant (SOT) both presenting high morbidity and mortality rates. Candidiasis and Aspergillosis are the major fungal infections among these patients and the failure of current antifungal therapies call for new therapeutic aids. Vaccination represents a valid alternative, and proof of concept of the efficacy of this approach has been provided at clinical level. This review will analyze current understanding of antifungal immunology, with a particular focus on genetic vaccination as a suitable strategy to counteract these diseases.
2021
anti-fungal; aspergillosis; genetic vaccination; hsct; immunotherapy; invasive fungal infections; sot; vaccine
01 Pubblicazione su rivista::01a Articolo in rivista
Genetic Vaccination as a Flexible Tool to Overcome the Immunological Complexity of Invasive Fungal Infections / Luberto, L.; Neroni, B.; Gandini, O.; Fiscarelli, E. V.; Salvatori, G.; Roscilli, G.; Marra, E.. - In: FRONTIERS IN MICROBIOLOGY. - ISSN 1664-302X. - 12:Dec 15(2021), pp. 1-8. [10.3389/fmicb.2021.789774]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1613957
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