Cardiac stromal cells have been long underestimated in their functions in homeostasis and repair. Recent evidence has changed this perspective in that many more players and facets than just “cardiac fibroblasts” have entered the field. Single cell transcriptomic studies on cardiac interstitial cells have shed light on the phenotypic plasticity of the stroma, whose transcriptional profile is dynamically regulated in homeostatic conditions and in response to external stimuli. Different populations and/or functional states that appear in homeostasis and pathology have been described, particularly increasing the complexity of studying the cardiac response to injury. In this review, we outline current phenotypical and molecular markers, and the approaches developed for identifying and classifying cardiac stromal cells. Significant advances in our understanding of cardiac stromal populations will provide a deeper knowledge on myocardial functional cellular components, as well as a platform for future developments of novel therapeutic strategies to counteract cardiac fibrosis and adverse cardiac remodeling.

The dynamic facets of the cardiac stroma. Fom classical markers to omics and translational perspectives / Picchio, Vittorio; Bordin, Antonella; Floris, Erica; Cozzolino, Claudia; Dhori, Xhulio; Peruzzi, Mariangela; Frati, Giacomo; DE FALCO, Elena; Pagano, Francesca; Chimenti, Isotta. - In: AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH. - ISSN 1943-8141. - 14:2(2022), pp. 1172-1187.

The dynamic facets of the cardiac stroma. Fom classical markers to omics and translational perspectives

Vittorio Picchio
Primo
;
Antonella Bordin;Erica Floris;Claudia Cozzolino;Mariangela Peruzzi;Giacomo Frati;Elena De Falco;Isotta Chimenti
Ultimo
2022

Abstract

Cardiac stromal cells have been long underestimated in their functions in homeostasis and repair. Recent evidence has changed this perspective in that many more players and facets than just “cardiac fibroblasts” have entered the field. Single cell transcriptomic studies on cardiac interstitial cells have shed light on the phenotypic plasticity of the stroma, whose transcriptional profile is dynamically regulated in homeostatic conditions and in response to external stimuli. Different populations and/or functional states that appear in homeostasis and pathology have been described, particularly increasing the complexity of studying the cardiac response to injury. In this review, we outline current phenotypical and molecular markers, and the approaches developed for identifying and classifying cardiac stromal cells. Significant advances in our understanding of cardiac stromal populations will provide a deeper knowledge on myocardial functional cellular components, as well as a platform for future developments of novel therapeutic strategies to counteract cardiac fibrosis and adverse cardiac remodeling.
2022
cardiac fibroblasts; cardiac stromal cells; fibroblast markers; cardiac fibrosis; heart failure; cardiac remodeling; single-cell sequencing; omics data
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
The dynamic facets of the cardiac stroma. Fom classical markers to omics and translational perspectives / Picchio, Vittorio; Bordin, Antonella; Floris, Erica; Cozzolino, Claudia; Dhori, Xhulio; Peruzzi, Mariangela; Frati, Giacomo; DE FALCO, Elena; Pagano, Francesca; Chimenti, Isotta. - In: AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH. - ISSN 1943-8141. - 14:2(2022), pp. 1172-1187.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1613913
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