Tamoxifen is the gold standard drug for the treatment of breast cancer in pre and post-menopausal women. Its journey from a failing contraceptive to a blockbuster is an example of pharmaceutical innovation challenges. Tamoxifen has a wide range of pharmacological activities; a drug that was initially thought to work via a simple Estrogen receptor (ER) mechanism was proven to mediate its activity through several non-ER mechanisms. Here in we review the previous literature describing ER and non-ER targets of tamoxifen, we highlighted the overlooked connection between tamoxifen, tamoxifen apoptotic effects and oxidative stress.
Tamoxifen and oxidative stress. An overlooked connection / Ahmed, N. S.; Samec, M.; Liskova, A.; Kubatka, P.; Saso, L.. - In: DISCOVER ONCOLOGY. - ISSN 2730-6011. - 12:1(2021), pp. 1-15. [10.1007/s12672-021-00411-y]
Tamoxifen and oxidative stress. An overlooked connection
Saso L.
2021
Abstract
Tamoxifen is the gold standard drug for the treatment of breast cancer in pre and post-menopausal women. Its journey from a failing contraceptive to a blockbuster is an example of pharmaceutical innovation challenges. Tamoxifen has a wide range of pharmacological activities; a drug that was initially thought to work via a simple Estrogen receptor (ER) mechanism was proven to mediate its activity through several non-ER mechanisms. Here in we review the previous literature describing ER and non-ER targets of tamoxifen, we highlighted the overlooked connection between tamoxifen, tamoxifen apoptotic effects and oxidative stress.| File | Dimensione | Formato | |
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Ahmed_Tamoxifen-oxidative-stress_2021.pdf
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