The cytoskeleton includes three main classes of networked filaments behaving as a coherent and complex structure that confers stability to cell shape while serving as sensor of internal/extracellular changes. Microenvironmental stimuli interfere with the non-linear dynamics that govern cytoskeleton architecture, namely by fostering symmetry breakings and transitions across different phenotypic states. Such process induces a whole-coherent adaptive response, involving the reprogramming of biochemical and gene-expression patterns. These characteristics are especially relevant during development, and in those conditions in which a deregulated crosstalk between cells and the stroma is at the core of the pathological process. Therefore, studying how the cytoskeleton can be modified–both pharmacologically and/or through microenvironment-dependent changes–has become a major area of interest in cancer and developmental biology.

Microenvironment promotes cytoskeleton remodeling and adaptive phenotypic transition / Bizzarri, M.; Pontecorvi, P.. - In: BIOCELL. - ISSN 0327-9545. - 46:6(2022), pp. 1357-1362. [10.32604/biocell.2022.018471]

Microenvironment promotes cytoskeleton remodeling and adaptive phenotypic transition

Bizzarri M.
;
Pontecorvi P.
2022

Abstract

The cytoskeleton includes three main classes of networked filaments behaving as a coherent and complex structure that confers stability to cell shape while serving as sensor of internal/extracellular changes. Microenvironmental stimuli interfere with the non-linear dynamics that govern cytoskeleton architecture, namely by fostering symmetry breakings and transitions across different phenotypic states. Such process induces a whole-coherent adaptive response, involving the reprogramming of biochemical and gene-expression patterns. These characteristics are especially relevant during development, and in those conditions in which a deregulated crosstalk between cells and the stroma is at the core of the pathological process. Therefore, studying how the cytoskeleton can be modified–both pharmacologically and/or through microenvironment-dependent changes–has become a major area of interest in cancer and developmental biology.
2022
Cell fate commitment; Cell scaffolding; Environmental cues; Non-equilibrium thermodynamics; Phenotypic reversion
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Microenvironment promotes cytoskeleton remodeling and adaptive phenotypic transition / Bizzarri, M.; Pontecorvi, P.. - In: BIOCELL. - ISSN 0327-9545. - 46:6(2022), pp. 1357-1362. [10.32604/biocell.2022.018471]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1613652
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