We report and discuss the synthesis and characterization of a new generation of radiolabeled 99mTc keratin gold nanoparticles (99mTc-Ker-AuNPs) to realize a new generation of biocompatible nanotherapeutics for the treatment of cancerous tissues via light assisted thermal therapy. The presence of 99mTc easily allows revealing the Ker-AuNPs accumulation in tissues, thus enabling a selective photothermal ablation. The 99mTc-Ker-AuNPs is investigated through instant thin-layer chromatography (ITLC), UV-Vis spectroscopy, and a high resolution thermographic optical setup, revealing a successful conjugation between99mTc-Ker and Ker-AuNPs along with excellent photothermal properties.
99mTc-labeled Keratin-coated gold nanoparticles for selective anticancer photothermal therapy / Frantellizzi, V.; Pontico, M.; de Vincentis, G.; Civitelli, L.; Petronella, F.; Pani, R.; Calogero, A.; Perotto, G.; de Sio, L.. - (2021). (Intervento presentato al convegno Biophotonics Congress: Optics in the Life Sciences tenutosi a Washington, DC; United States).
99mTc-labeled Keratin-coated gold nanoparticles for selective anticancer photothermal therapy
Frantellizzi V.Primo
;Pontico M.Secondo
;de Vincentis G.;Civitelli L.;Pani R.;Calogero A.;de Sio L.Ultimo
2021
Abstract
We report and discuss the synthesis and characterization of a new generation of radiolabeled 99mTc keratin gold nanoparticles (99mTc-Ker-AuNPs) to realize a new generation of biocompatible nanotherapeutics for the treatment of cancerous tissues via light assisted thermal therapy. The presence of 99mTc easily allows revealing the Ker-AuNPs accumulation in tissues, thus enabling a selective photothermal ablation. The 99mTc-Ker-AuNPs is investigated through instant thin-layer chromatography (ITLC), UV-Vis spectroscopy, and a high resolution thermographic optical setup, revealing a successful conjugation between99mTc-Ker and Ker-AuNPs along with excellent photothermal properties.| File | Dimensione | Formato | |
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Note: https://opg.optica.org/abstract.cfm?uri=OMP-2021-OTu1E.5
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