Epidemiological studies aimed at defining the association of thyroid diseases with extrathyroidal malignancies (EM) have aroused considerable interest in the possibility of revealing common genetic and environmental factors underlying disease etiology and progression. Over the years, multiple lines of evidence indicated a significant relationship between thyroid carcinomas and other primary EM, especially breast cancer. For the latter, a prominent association was also found with benign thyroid diseases. In particular, a meta-analysis revealed an increased risk of breast cancer in patients with autoimmune thyroiditis, and our recent work demonstrated that the odds ratio (OR) for breast cancer was raised in both thyroid autoantibody-positive and-negative patients. However, the OR was significantly lower for thyroid autoantibody-positive patients compared to the negative ones. This is in agreement with findings showing that the development of thyroid autoimmunity in cancer patients receiving immunotherapy is associated with better outcome and supports clinical evidence that breast cancer patients with thyroid autoimmunity have longer disease-free interval and overall survival. These results seem to suggest that factors other than oncologic treatments may play a role in the initiation and progression of a second primary malignancy. The molecular links between thyroid autoimmunity and breast cancer remain, however, unidentified, and different hypotheses have been proposed. Here, we will review the epidemiological, clinical, and experimental data relating thyroid diseases and breast cancer, as well as the possible hormonal and molecular mechanisms underlying such associations.

Thyroid diseases and breast cancer / Baldini, E.; Lauro, A.; Tripodi, D.; Pironi, D.; Amabile, M. I.; Ferent, I. C.; Lori, E.; Gagliardi, F.; Bellini, M. I.; Forte, F.; Pacini, P.; Cantisani, V.; D'andrea, V.; Sorrenti, S.; Ulisse, S.. - In: JOURNAL OF PERSONALIZED MEDICINE. - ISSN 2075-4426. - 12:2(2022). [10.3390/jpm12020156]

Thyroid diseases and breast cancer

Baldini E.
Primo
;
Lauro A.
Secondo
;
Tripodi D.;Pironi D.;Amabile M. I.;Ferent I. C.;Lori E.;Gagliardi F.;Bellini M. I.;Forte F.;Pacini P.;Cantisani V.;D'andrea V.;Sorrenti S.
Penultimo
;
Ulisse S.
Ultimo
2022

Abstract

Epidemiological studies aimed at defining the association of thyroid diseases with extrathyroidal malignancies (EM) have aroused considerable interest in the possibility of revealing common genetic and environmental factors underlying disease etiology and progression. Over the years, multiple lines of evidence indicated a significant relationship between thyroid carcinomas and other primary EM, especially breast cancer. For the latter, a prominent association was also found with benign thyroid diseases. In particular, a meta-analysis revealed an increased risk of breast cancer in patients with autoimmune thyroiditis, and our recent work demonstrated that the odds ratio (OR) for breast cancer was raised in both thyroid autoantibody-positive and-negative patients. However, the OR was significantly lower for thyroid autoantibody-positive patients compared to the negative ones. This is in agreement with findings showing that the development of thyroid autoimmunity in cancer patients receiving immunotherapy is associated with better outcome and supports clinical evidence that breast cancer patients with thyroid autoimmunity have longer disease-free interval and overall survival. These results seem to suggest that factors other than oncologic treatments may play a role in the initiation and progression of a second primary malignancy. The molecular links between thyroid autoimmunity and breast cancer remain, however, unidentified, and different hypotheses have been proposed. Here, we will review the epidemiological, clinical, and experimental data relating thyroid diseases and breast cancer, as well as the possible hormonal and molecular mechanisms underlying such associations.
2022
breast cancer; epidemiology; etiology; extra-thyroidal malignancies; thyroid disease
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Thyroid diseases and breast cancer / Baldini, E.; Lauro, A.; Tripodi, D.; Pironi, D.; Amabile, M. I.; Ferent, I. C.; Lori, E.; Gagliardi, F.; Bellini, M. I.; Forte, F.; Pacini, P.; Cantisani, V.; D'andrea, V.; Sorrenti, S.; Ulisse, S.. - In: JOURNAL OF PERSONALIZED MEDICINE. - ISSN 2075-4426. - 12:2(2022). [10.3390/jpm12020156]
File allegati a questo prodotto
File Dimensione Formato  
Baldini_Thyroid diseases_2022.pdf

accesso aperto

Note: https://www.mdpi.com/2075-4426/12/2/156
Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 921.6 kB
Formato Adobe PDF
921.6 kB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1612212
Citazioni
  • ???jsp.display-item.citation.pmc??? 10
  • Scopus 14
  • ???jsp.display-item.citation.isi??? 12
social impact