During the COVID-19 pandemic, multiple theories were proposed based on the observation that countries with an ongoing national Bacillus Calmette-Gue´rin (BCG) immunization programme had lower SARS-CoV-2 case rates and COVID-19 mortality than countries that had stopped BCG vaccine administration. There was, however, no evidence supporting or disputing this theory1,2 . Owing to the uncertainty on the role of BCG vaccine on the outcomes of patients with perioperative SARS-CoV-2 infection, this international study aimed to determine whether previous BCG vaccination was associated with reduced postoperative pulmonary complications (PPC) and 30-day mortality in patients undergoing surgery who developed SARS-CoV-2 infection
Impact of Bacillus Calmette-Guérin (BCG) vaccination on postoperative mortality in patients with perioperative SARS-CoV-2 infection / Lapolla, P; Mingoli, A; De Toma, G; Fiori, E; La Torre, F; Sapienza, P; Brachini, G; Cirillo, B; Iannone, I; Zambon, M; Chiappini, A; Meneghini, S; Fonsi, Gb; Cicerchia, Pm; Bruzzaniti, P; Santoro, A; Frati, A; Marruzzo, G; Ribuffo, D; Familiari, P; D’Andrea, G; Picotti, V; Bàmbina, F. - In: BJS OPEN. - ISSN 2474-9842. - 5:6(2022). [10.1093/bjsopen/zrab131]
Impact of Bacillus Calmette-Guérin (BCG) vaccination on postoperative mortality in patients with perioperative SARS-CoV-2 infection
Lapolla P;Mingoli A;De Toma G;Fiori E;La Torre F;Sapienza P;Brachini G;Cirillo B;Iannone I;Chiappini A;Meneghini S;Fonsi GB;Cicerchia PM;Bruzzaniti P;Santoro A;Frati A;Marruzzo G;Ribuffo D;Familiari P;Picotti V;Bàmbina F
2022
Abstract
During the COVID-19 pandemic, multiple theories were proposed based on the observation that countries with an ongoing national Bacillus Calmette-Gue´rin (BCG) immunization programme had lower SARS-CoV-2 case rates and COVID-19 mortality than countries that had stopped BCG vaccine administration. There was, however, no evidence supporting or disputing this theory1,2 . Owing to the uncertainty on the role of BCG vaccine on the outcomes of patients with perioperative SARS-CoV-2 infection, this international study aimed to determine whether previous BCG vaccination was associated with reduced postoperative pulmonary complications (PPC) and 30-day mortality in patients undergoing surgery who developed SARS-CoV-2 infection| File | Dimensione | Formato | |
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Impact-of-Bacillus_2022.pdf
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