During the COVID-19 pandemic, multiple theories were proposed based on the observation that countries with an ongoing national Bacillus Calmette-Gue´rin (BCG) immunization programme had lower SARS-CoV-2 case rates and COVID-19 mortality than countries that had stopped BCG vaccine administration. There was, however, no evidence supporting or disputing this theory1,2 . Owing to the uncertainty on the role of BCG vaccine on the outcomes of patients with perioperative SARS-CoV-2 infection, this international study aimed to determine whether previous BCG vaccination was associated with reduced postoperative pulmonary complications (PPC) and 30-day mortality in patients undergoing surgery who developed SARS-CoV-2 infection
Impact of Bacillus Calmette-Guérin (BCG) vaccination on postoperative mortality in patients with perioperative SARS-CoV-2 infection / Lapolla, P., Mingoli, A., De Toma, G., Fiori, E., La Torre, F., Sapienza, P., Brachini, G., Cirillo, B., Iannone, I., Zambon, M., Chiappini, A., Meneghini, S., Fonsi, G.b., Cicerchia, P.m., Bruzzaniti, P., Santoro, A., Frati, A., Marruzzo, G., Ribuffo, D., Familiari, P., et al.. - In: BJS OPEN. - ISSN 2474-9842. - 5:6(2022). [10.1093/bjsopen/zrab131]
Impact of Bacillus Calmette-Guérin (BCG) vaccination on postoperative mortality in patients with perioperative SARS-CoV-2 infection
Lapolla P;Mingoli A;De Toma G;Fiori E;La Torre F;Sapienza P;Brachini G;Cirillo B;Iannone I;Zambon M;Chiappini A;Meneghini S;Fonsi GB;Cicerchia PM;Bruzzaniti P;Santoro A;Frati A;Marruzzo G;Ribuffo D;Familiari P;Picotti V;Bàmbina F
2022
Abstract
During the COVID-19 pandemic, multiple theories were proposed based on the observation that countries with an ongoing national Bacillus Calmette-Gue´rin (BCG) immunization programme had lower SARS-CoV-2 case rates and COVID-19 mortality than countries that had stopped BCG vaccine administration. There was, however, no evidence supporting or disputing this theory1,2 . Owing to the uncertainty on the role of BCG vaccine on the outcomes of patients with perioperative SARS-CoV-2 infection, this international study aimed to determine whether previous BCG vaccination was associated with reduced postoperative pulmonary complications (PPC) and 30-day mortality in patients undergoing surgery who developed SARS-CoV-2 infection| File | Dimensione | Formato | |
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Impact-of-Bacillus_2022.pdf
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Note: https://academic.oup.com/bjsopen/article/5/6/zrab131/6504756?login=true
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