Host genomic information, specifically genomic variations, may characterize susceptibility to disease and identify people with a higher risk of harm, leading to better targeting of care and vaccination. Italy was the epicentre for the spread of COVID-19 in Europe, the first country to go into a national lockdown and has one of the highest COVID-19 associated mortality rates. Qatar, on the other hand has a very low mortality rate. In this study, we compared whole-genome sequencing data of 14398 adults and Qatari-national to 925 Italian individuals. We also included in the comparison whole-exome sequence data from 189 Italian laboratory-confirmed COVID-19 cases. We focused our study on a curated list of 3619 candidate genes involved in innate immunity and host-pathogen interaction. Two population-gene metric scores, the Delta Singleton-Cohort variant score (DSC) and Sum Singleton-Cohort variant score (SSC), were applied to estimate the presence of selective constraints in the Qatari population and in the Italian cohorts. Results based on DSC and SSC metrics demonstrated a different selective pressure on three genes (MUC5AC, ABCA7, FLNA) between Qatari and Italian populations. This study highlighted the genetic differences between Qatari and Italian populations and identified a subset of genes involved in innate immunity and host-pathogen interaction.

Poking COVID-19: insights on genomic constraints among immune-related genes between Qatari and Italian populations / Mbarek, H.; Cocca, M.; Al-Sarraj, Y.; Saad, C.; Mezzavilla, M.; Almuftah, W.; Cocciadiferro, D.; Novelli, A.; Quinti, I.; Altawashi, A.; Salvaggio, S.; Althani, A.; Novelli, G.; Ismail, S. I.. - In: GENES. - ISSN 2073-4425. - 12:11(2021). [10.3390/genes12111842]

Poking COVID-19: insights on genomic constraints among immune-related genes between Qatari and Italian populations

Quinti I.;
2021

Abstract

Host genomic information, specifically genomic variations, may characterize susceptibility to disease and identify people with a higher risk of harm, leading to better targeting of care and vaccination. Italy was the epicentre for the spread of COVID-19 in Europe, the first country to go into a national lockdown and has one of the highest COVID-19 associated mortality rates. Qatar, on the other hand has a very low mortality rate. In this study, we compared whole-genome sequencing data of 14398 adults and Qatari-national to 925 Italian individuals. We also included in the comparison whole-exome sequence data from 189 Italian laboratory-confirmed COVID-19 cases. We focused our study on a curated list of 3619 candidate genes involved in innate immunity and host-pathogen interaction. Two population-gene metric scores, the Delta Singleton-Cohort variant score (DSC) and Sum Singleton-Cohort variant score (SSC), were applied to estimate the presence of selective constraints in the Qatari population and in the Italian cohorts. Results based on DSC and SSC metrics demonstrated a different selective pressure on three genes (MUC5AC, ABCA7, FLNA) between Qatari and Italian populations. This study highlighted the genetic differences between Qatari and Italian populations and identified a subset of genes involved in innate immunity and host-pathogen interaction.
2021
COVID-19; COVID-19 severity; genetic constraints; population genetics
01 Pubblicazione su rivista::01a Articolo in rivista
Poking COVID-19: insights on genomic constraints among immune-related genes between Qatari and Italian populations / Mbarek, H.; Cocca, M.; Al-Sarraj, Y.; Saad, C.; Mezzavilla, M.; Almuftah, W.; Cocciadiferro, D.; Novelli, A.; Quinti, I.; Altawashi, A.; Salvaggio, S.; Althani, A.; Novelli, G.; Ismail, S. I.. - In: GENES. - ISSN 2073-4425. - 12:11(2021). [10.3390/genes12111842]
File allegati a questo prodotto
File Dimensione Formato  
Mbarek_Poking-Covid19_2021.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 1.99 MB
Formato Adobe PDF
1.99 MB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1611982
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
social impact