MicroRNAs (miRNA) are small, noncoding RNAs, approximately 19–24 nucleotides in length, which regulate gene expression at the transcriptional level. Very recently, alterations of four plasma miRNAs (miR-130a, miR26a, miR-30c, and let-7f) were reported in central hypersomnias, as expression of their involvement in the pathophysiology of narcolepsy and idiopathic hypersomnia. The increased expression of both miR-155 and miR125b in N1 DQB1*06:02 narcolepsy drug-naïve patients, examined close to the pathology burst, could instill the possibility of an inflammatory cascade, also counting proinflammatory miRNAs, evident at disease onset in orexin-deficient narcolepsy patients. Although these findings do not allow us to test the hypothesis of a relationship between inflammatory miRNAs and narcolepsy, we would suggest the possible overexpression of these miRNAs subtypes in N1 patients close to disease onset. Yet, larger investigations are needed in the future to better determine if there is a causal association among inflammation, miRNAs, and narcolepsy.
MicroRNA expression is dysregulated in narcolepsy: A new evidence? / Liguori, C.; Dinallo, V.; Pieri, M.; Izzi, F.; Romigi, A.; Ialongo, C.; Marciani, M. G.; Bernardini, S.; Mercuri, N. B.; Placidi, F.. - In: SLEEP MEDICINE. - ISSN 1389-9457. - 16:8(2015), pp. 1027-1028. [10.1016/j.sleep.2015.03.016]
MicroRNA expression is dysregulated in narcolepsy: A new evidence?
Liguori C.;Izzi F.;Ialongo C.;
2015
Abstract
MicroRNAs (miRNA) are small, noncoding RNAs, approximately 19–24 nucleotides in length, which regulate gene expression at the transcriptional level. Very recently, alterations of four plasma miRNAs (miR-130a, miR26a, miR-30c, and let-7f) were reported in central hypersomnias, as expression of their involvement in the pathophysiology of narcolepsy and idiopathic hypersomnia. The increased expression of both miR-155 and miR125b in N1 DQB1*06:02 narcolepsy drug-naïve patients, examined close to the pathology burst, could instill the possibility of an inflammatory cascade, also counting proinflammatory miRNAs, evident at disease onset in orexin-deficient narcolepsy patients. Although these findings do not allow us to test the hypothesis of a relationship between inflammatory miRNAs and narcolepsy, we would suggest the possible overexpression of these miRNAs subtypes in N1 patients close to disease onset. Yet, larger investigations are needed in the future to better determine if there is a causal association among inflammation, miRNAs, and narcolepsy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
