EHMTI-0241. Association between migraine and sod1 and sod2 genes polymorphisms: the biobim study

The SOD1 gene presents a polymorphism (A/C substitution - rs2234694) resulting in lower serum activitiy in subjects carrying CC genotype. SOD2 gene presents a polymorphism (C/T transition -rs4880 – Ala16Val) which leads to an instable mRNA and reduced transport of the enzyme in TT genotype carriers. We aimed at investigating whether these variants are associated to migraine without aura (MO), migraine with aura (MA), or chronic migraine (CM) in a cohort of Caucasian patients from the Interinstitutional Multidisciplinary BioBank (BioBIM). SOD2 TT genotype correlates with MA with UAs. We hypothesize that in SOD2 TT carriers with MA, a defective control of oxidative phenomena characterizing cortical spreading depression leads to a more intense antidromic stimulation of trigeminal endings, thus triggering the trigemino-autonomic reflex.