Stimuli-sensitive nanocarriers have recently been developed as a powerful tool in biomedi-cal applications such as drug delivery, detection, and gene transfer techniques. Among the external triggers investigated, low intensity magnetic fields represent a non-invasive way to remotely control the release of compounds from a magneto-sensitive carrier. Magnetoliposomes (MLs), i.e., liposomes entrapping magnetic nanoparticles (MNPs), are studied due to their capacity to transport hydropho-bic and hydrophilic agents, their easy production, and due to the ability of MNPs to respond to a magnetic actuation determining the triggered release of the encapsulated compounds. Here we investigated the design and optimization of the MLs to obtain an efficient on-demand release of the transported compounds, due to the magneto-mechanical actuation induced by applying low-intensity pulsed electromagnetic fields (PEMFs). In particular we studied the effect of the bilayer packing on the ability of MLs, with oleic acid-coated MNPs encapsulated in the bilayer, to respond to PEMFs application. Three kinds of MLs are produced with an increasing rigidity of the bilayer, defined as Liquid Disorder, Liquid Order, and Gel MLs and the delivery of a hydrophilic dye (as a model drug) is investigated. Results demonstrate the efficacy of the magnetic trigger on high-ordered bilayers, which are unable to dampen the perturbation produced by MNPs motion.

The impact of bilayer rigidity on the release from magnetoliposomes vesicles controlled by pemfs / Trilli, J.; Caramazza, L.; Paolicelli, P.; Casadei, M. A.; Liberti, M.; Apollonio, F.; Petralito, S.. - In: PHARMACEUTICS. - ISSN 1999-4923. - 13:10(2021), pp. 1-14. [10.3390/pharmaceutics13101712]

The impact of bilayer rigidity on the release from magnetoliposomes vesicles controlled by pemfs

Trilli J.;Caramazza L.;Paolicelli P.;Casadei M. A.;Liberti M.;Apollonio F.
;
Petralito S.
2021

Abstract

Stimuli-sensitive nanocarriers have recently been developed as a powerful tool in biomedi-cal applications such as drug delivery, detection, and gene transfer techniques. Among the external triggers investigated, low intensity magnetic fields represent a non-invasive way to remotely control the release of compounds from a magneto-sensitive carrier. Magnetoliposomes (MLs), i.e., liposomes entrapping magnetic nanoparticles (MNPs), are studied due to their capacity to transport hydropho-bic and hydrophilic agents, their easy production, and due to the ability of MNPs to respond to a magnetic actuation determining the triggered release of the encapsulated compounds. Here we investigated the design and optimization of the MLs to obtain an efficient on-demand release of the transported compounds, due to the magneto-mechanical actuation induced by applying low-intensity pulsed electromagnetic fields (PEMFs). In particular we studied the effect of the bilayer packing on the ability of MLs, with oleic acid-coated MNPs encapsulated in the bilayer, to respond to PEMFs application. Three kinds of MLs are produced with an increasing rigidity of the bilayer, defined as Liquid Disorder, Liquid Order, and Gel MLs and the delivery of a hydrophilic dye (as a model drug) is investigated. Results demonstrate the efficacy of the magnetic trigger on high-ordered bilayers, which are unable to dampen the perturbation produced by MNPs motion.
2021
magneto mechanical trigger; magneto nanoparticles; magnetoliposomes; non-thermal magnetic field; on-demand drug delivery; pulsed electromagnetic fields
01 Pubblicazione su rivista::01a Articolo in rivista
The impact of bilayer rigidity on the release from magnetoliposomes vesicles controlled by pemfs / Trilli, J.; Caramazza, L.; Paolicelli, P.; Casadei, M. A.; Liberti, M.; Apollonio, F.; Petralito, S.. - In: PHARMACEUTICS. - ISSN 1999-4923. - 13:10(2021), pp. 1-14. [10.3390/pharmaceutics13101712]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1610771
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