Previous evidence showed abnormal parietal sources of resting-state electroencephalographic (EEG) delta (< 4 Hz) and alpha (8–12 Hz) rhythms in treatment-Naïve HIV (Naïve HIV) subjects, as cortical neural synchroni- zation markers in quiet wakefulness. Here, we tested the hypothesis that these local abnormalities may be related to functional cortical dysconnectivity as an oscillatory brain network disorder. The present EEG database regarded 128 Naïve HIV and 60 Healthy subjects. The eLORETA freeware estimated lagged linear EEG source connectivity (LLC). The area under receiver operating characteristic (AUROC) curve indexed the accuracy in the classification between Healthy and HIV individuals. Parietal intrahemispheric LLC solutions in alpha sources were abnormally lower in the Naïve HIV than in the control group. Furthermore, those abnormalities were greater in the Naïve HIV subgroup with executive and visuospatial deficits than the Naïve HIV subgroup with normal cognition. AUROC curves of those LLC solutions exhibited moderate/good accuracies (0.75–0.88) in the discrimination between the Naïve HIV individuals with executive and visuospatial deficits vs. Naïve HIV individuals with normal cognition and control individuals.In quiet wakefulness, Naïve HIV subjects showed clinically relevant abnormalities in parietal alpha source connectivity. HIV may alter a parietal “hub” oscillating at the alpha frequency in quiet wakefulness as a brain network disorder.

Parietal intrahemispheric source connectivity of resting-state electroencephalographic alpha rhythms is abnormal in Naïve HIV patients / Babilonia, Claudio; DEL PERCIO, Claudio; Lizio, Roberta; Lopez, Susanna; Pennica, Alfredo; Roma, Paolo; Correr, Valentina; Cucciolla, Federica; Toma, Ginevra; Soricelli, Andrea; Di Campli, Francesco; Aceti, Antonio; Teti, Elisabetta; Sarmati, Loredana; Crocetti, Gloria; Ferri, Raffaele; Lorenzo, Ivan; Galli, Massimo; Negri, Cristina; Angarano, Gioacchino; Saracino, Annalisa; Lepore, Luciana; Di Pietro, Massimo; Maria Fusco, Francesco; Vullo, Vincenzo; D’Ettorre, Gabriella; Pagliano, Pasquale; Di Flumeri, Giusy; Maurizio Celesia, Benedetto; Gentilini Cacciola, Elio; Di Perri, Giovanni; Calcagno, Andrea; Stocchi, Fabrizio; Ferracuti, Stefano; Onorati, Paolo; Andreoni, Massimo; Noce, Giuseppe. - In: BRAIN RESEARCH BULLETIN. - ISSN 0361-9230. - 181:(2022), pp. 129-143. [10.1016/j.brainresbull.2022.01.015]

Parietal intrahemispheric source connectivity of resting-state electroencephalographic alpha rhythms is abnormal in Naïve HIV patients

Claudio Del Percio;Roberta Lizio;Susanna Lopez;Paolo Roma;Ginevra Toma;Vincenzo Vullo;Gabriella D’Ettorre;Fabrizio Stocchi;Stefano Ferracuti;Paolo Onorati;Giuseppe Noce
2022

Abstract

Previous evidence showed abnormal parietal sources of resting-state electroencephalographic (EEG) delta (< 4 Hz) and alpha (8–12 Hz) rhythms in treatment-Naïve HIV (Naïve HIV) subjects, as cortical neural synchroni- zation markers in quiet wakefulness. Here, we tested the hypothesis that these local abnormalities may be related to functional cortical dysconnectivity as an oscillatory brain network disorder. The present EEG database regarded 128 Naïve HIV and 60 Healthy subjects. The eLORETA freeware estimated lagged linear EEG source connectivity (LLC). The area under receiver operating characteristic (AUROC) curve indexed the accuracy in the classification between Healthy and HIV individuals. Parietal intrahemispheric LLC solutions in alpha sources were abnormally lower in the Naïve HIV than in the control group. Furthermore, those abnormalities were greater in the Naïve HIV subgroup with executive and visuospatial deficits than the Naïve HIV subgroup with normal cognition. AUROC curves of those LLC solutions exhibited moderate/good accuracies (0.75–0.88) in the discrimination between the Naïve HIV individuals with executive and visuospatial deficits vs. Naïve HIV individuals with normal cognition and control individuals.In quiet wakefulness, Naïve HIV subjects showed clinically relevant abnormalities in parietal alpha source connectivity. HIV may alter a parietal “hub” oscillating at the alpha frequency in quiet wakefulness as a brain network disorder.
2022
human immunodeficiency virus (HIV); functional brain connectivity; resting-state EEG rhythms; exact low-resolution brain electromagnetic source tomography (eLORETA)
01 Pubblicazione su rivista::01a Articolo in rivista
Parietal intrahemispheric source connectivity of resting-state electroencephalographic alpha rhythms is abnormal in Naïve HIV patients / Babilonia, Claudio; DEL PERCIO, Claudio; Lizio, Roberta; Lopez, Susanna; Pennica, Alfredo; Roma, Paolo; Correr, Valentina; Cucciolla, Federica; Toma, Ginevra; Soricelli, Andrea; Di Campli, Francesco; Aceti, Antonio; Teti, Elisabetta; Sarmati, Loredana; Crocetti, Gloria; Ferri, Raffaele; Lorenzo, Ivan; Galli, Massimo; Negri, Cristina; Angarano, Gioacchino; Saracino, Annalisa; Lepore, Luciana; Di Pietro, Massimo; Maria Fusco, Francesco; Vullo, Vincenzo; D’Ettorre, Gabriella; Pagliano, Pasquale; Di Flumeri, Giusy; Maurizio Celesia, Benedetto; Gentilini Cacciola, Elio; Di Perri, Giovanni; Calcagno, Andrea; Stocchi, Fabrizio; Ferracuti, Stefano; Onorati, Paolo; Andreoni, Massimo; Noce, Giuseppe. - In: BRAIN RESEARCH BULLETIN. - ISSN 0361-9230. - 181:(2022), pp. 129-143. [10.1016/j.brainresbull.2022.01.015]
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