Multiple sclerosis (MS) is the most common inflammatory disorder of the central nervous system (CNS) in young adults. When MS is not treated, it leads to irreversible and severe disability. The etiology of MS and its pathogenesis are not fully understood. The recent discovery that MS-associated genetic variants code for molecules related to the function of specific immune cell subsets is consistent with the concept of MS as a prototypic, T-cell-mediated autoimmune disease targeting the CNS. While the therapeutic efficacy of the currently available immunomodulatory therapies further strengthen this concept, differences observed in responses to MS treatment as well as additional clinical and imaging observations have also shown that the autoimmune pathogenesis underlying MS is much more complex than previously thought. There is therefore an unmet need for continued detailed phenotypic and functional analysis of disease-relevant adaptive immune cells and tissues directly derived from MS patients to unravel the immune etiology of MS in its entire complexity. In this review, we will discuss the currently available MS treatment options and approved drugs, including how they have contributed to the understanding of the immune pathology of this autoimmune disease.

Current multiple sclerosis treatments have improved our understanding of MS autoimmune pathogenesis / Martin, R.; Sospedra, M.; Rosito, M.; Engelhardt, B.. - In: EUROPEAN JOURNAL OF IMMUNOLOGY. - ISSN 0014-2980. - 46:9(2016), pp. 2078-2090. [10.1002/eji.201646485]

Current multiple sclerosis treatments have improved our understanding of MS autoimmune pathogenesis

Rosito M.;
2016

Abstract

Multiple sclerosis (MS) is the most common inflammatory disorder of the central nervous system (CNS) in young adults. When MS is not treated, it leads to irreversible and severe disability. The etiology of MS and its pathogenesis are not fully understood. The recent discovery that MS-associated genetic variants code for molecules related to the function of specific immune cell subsets is consistent with the concept of MS as a prototypic, T-cell-mediated autoimmune disease targeting the CNS. While the therapeutic efficacy of the currently available immunomodulatory therapies further strengthen this concept, differences observed in responses to MS treatment as well as additional clinical and imaging observations have also shown that the autoimmune pathogenesis underlying MS is much more complex than previously thought. There is therefore an unmet need for continued detailed phenotypic and functional analysis of disease-relevant adaptive immune cells and tissues directly derived from MS patients to unravel the immune etiology of MS in its entire complexity. In this review, we will discuss the currently available MS treatment options and approved drugs, including how they have contributed to the understanding of the immune pathology of this autoimmune disease.
2016
Autoantibodies; Autoimmune pathogenesis; Autoimmunity; Autoreactive B cells; Autoreactive T cells; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Treatment; Animals; Autoimmune Diseases; Biomarkers; Central Nervous System; Combined Modality Therapy; Hematopoietic Stem Cell Transplantation; Humans; Immunity, Innate; Molecular Targeted Therapy; Multiple Sclerosis; T-Lymphocytes; Autoimmunity
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Current multiple sclerosis treatments have improved our understanding of MS autoimmune pathogenesis / Martin, R.; Sospedra, M.; Rosito, M.; Engelhardt, B.. - In: EUROPEAN JOURNAL OF IMMUNOLOGY. - ISSN 0014-2980. - 46:9(2016), pp. 2078-2090. [10.1002/eji.201646485]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1608984
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