We present an optoelectronic system-on-glass for on-chip quantitative detection of a specific analyte in a biological solution. The system includes an amorphous silicon photodetector and an optical waveguide, integrated on a single glass substrate. The solution under investigation is placed on a waveguide's region where a monochromatic light is travelling. Light coupling depends on the sample's optical properties. Two different waveguiding structures have been investigated: glass-made waveguides, obtained by the double ion-exchange method on the glass substrate, and SU-8 polymer waveguides, obtained by photolithography. Optical losses around 0.5 dB/cm at 532 nm were achieved. The analyte detection is performed by a thin-film amorphous silicon p/i/n junction, fabricated with microelectronic technologies. The tested photodiodes present shot noise currents of about 2 fA/sqrt(Hz) and responsivity around 500 mA/W at 532 nm. As proof of concept, hemoglobin was studied as analyte for a demonstration scenario, involving optical simulations interpolated with experimental data, resulting in a detection limit around 100 ppm, in line with well-established colorimetric methods currently on the market.
Optical detection of analytes through evanescent waves in lab-on-chip devices / Buzzin, A.; Asquini, R.; Caputo, D.; De Cesare, G.. - 2021:(2021), pp. 1793-1798. (Intervento presentato al convegno 44th International Convention on Information, Communication and Electronic Technology, MIPRO 2021 tenutosi a Opatija; Croatia) [10.23919/MIPRO52101.2021.9597132].
Optical detection of analytes through evanescent waves in lab-on-chip devices
Buzzin A.;Asquini R.;Caputo D.;De Cesare G.
2021
Abstract
We present an optoelectronic system-on-glass for on-chip quantitative detection of a specific analyte in a biological solution. The system includes an amorphous silicon photodetector and an optical waveguide, integrated on a single glass substrate. The solution under investigation is placed on a waveguide's region where a monochromatic light is travelling. Light coupling depends on the sample's optical properties. Two different waveguiding structures have been investigated: glass-made waveguides, obtained by the double ion-exchange method on the glass substrate, and SU-8 polymer waveguides, obtained by photolithography. Optical losses around 0.5 dB/cm at 532 nm were achieved. The analyte detection is performed by a thin-film amorphous silicon p/i/n junction, fabricated with microelectronic technologies. The tested photodiodes present shot noise currents of about 2 fA/sqrt(Hz) and responsivity around 500 mA/W at 532 nm. As proof of concept, hemoglobin was studied as analyte for a demonstration scenario, involving optical simulations interpolated with experimental data, resulting in a detection limit around 100 ppm, in line with well-established colorimetric methods currently on the market.File | Dimensione | Formato | |
---|---|---|---|
Buzzin_Optical-detection_2021.pdf
solo gestori archivio
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
384.23 kB
Formato
Adobe PDF
|
384.23 kB | Adobe PDF | Contatta l'autore |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.