In the last years the link between the presence of muscular alterations and hepatic en-cephalopathy (HE), both minimal and overt, has been deeply studied. The pathophysiological background supporting the relationship between muscle depletion, and HE is characterized by an imbalance between the capacity of muscle in ammonia metabolism and trafficking and the inability of the liver in removing ammonia through urea synthesis due to liver failure and/or the presence of porto-systemic shunts. This review will focus on the clinical burden, the physio pathological mechanisms understanding the liver muscle axis and principles of management of muscular alterations in cirrhosis.

Ammonia and the muscle: an emerging point of view on hepatic encephalopathy / Di Cola, S.; Nardelli, S.; Ridola, L.; Gioia, S.; Riggio, O.; Merli, M.. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 11:3(2022), pp. 1-12. [10.3390/jcm11030611]

Ammonia and the muscle: an emerging point of view on hepatic encephalopathy

Di Cola S.;Nardelli S.;Ridola L.;Gioia S.;Riggio O.;Merli M.
2022

Abstract

In the last years the link between the presence of muscular alterations and hepatic en-cephalopathy (HE), both minimal and overt, has been deeply studied. The pathophysiological background supporting the relationship between muscle depletion, and HE is characterized by an imbalance between the capacity of muscle in ammonia metabolism and trafficking and the inability of the liver in removing ammonia through urea synthesis due to liver failure and/or the presence of porto-systemic shunts. This review will focus on the clinical burden, the physio pathological mechanisms understanding the liver muscle axis and principles of management of muscular alterations in cirrhosis.
File allegati a questo prodotto
File Dimensione Formato  
Di Cola_Ammonia_2022.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 299.79 kB
Formato Adobe PDF
299.79 kB Adobe PDF Visualizza/Apri PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/1607578
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 0
social impact