Extracellular vesicles (EVs) are heterogenous membrane-encapsulated vesicles secreted by every cell into the extracellular environment. EVs carry bioactive molecules, including proteins, lipids, DNA, and different RNA forms, which can be internalized by recipient cells, thus altering their biological characteristics. Given that EVs are commonly found in most body fluids, they have been widely described as mediators of communication in several physiological and pathological processes, including cancer. Moreover, their easy detection in biofluids makes them potentially useful candidates as tumor biomarkers. In this manuscript, we review the current knowledge regarding EVs and non-coding RNAs and their role as drivers of the metastatic process in lung cancer. Furthermore, we present the most recent applications for EVs and non-coding RNAs as cancer therapeutics and their relevance as clinical biomarkers.

Extracellular vesicles in lung cancer metastasis and their clinical applications / Saviana, M.; Romano, G.; Le, P.; Acunzo, M.; Nana-Sinkam, P.. - In: CANCERS. - ISSN 2072-6694. - 13:22(2021). [10.3390/cancers13225633]

Extracellular vesicles in lung cancer metastasis and their clinical applications

Saviana M.;
2021

Abstract

Extracellular vesicles (EVs) are heterogenous membrane-encapsulated vesicles secreted by every cell into the extracellular environment. EVs carry bioactive molecules, including proteins, lipids, DNA, and different RNA forms, which can be internalized by recipient cells, thus altering their biological characteristics. Given that EVs are commonly found in most body fluids, they have been widely described as mediators of communication in several physiological and pathological processes, including cancer. Moreover, their easy detection in biofluids makes them potentially useful candidates as tumor biomarkers. In this manuscript, we review the current knowledge regarding EVs and non-coding RNAs and their role as drivers of the metastatic process in lung cancer. Furthermore, we present the most recent applications for EVs and non-coding RNAs as cancer therapeutics and their relevance as clinical biomarkers.
2021
extracellular vesicles; lung cancer; metastasis; non-coding RNA; therapy
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Extracellular vesicles in lung cancer metastasis and their clinical applications / Saviana, M.; Romano, G.; Le, P.; Acunzo, M.; Nana-Sinkam, P.. - In: CANCERS. - ISSN 2072-6694. - 13:22(2021). [10.3390/cancers13225633]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1607506
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