Acute lymphoblastic leukaemia (ALL) is an aggressive haematological tumour driven by the malignant transformation and expansion of B-cell (B-ALL) or T-cell (T-ALL) progenitors. The evolution of T-ALL pathogenesis encompasses different master developmental pathways, including the main role played by Notch in cell fate choices during tissue differentiation. Recently, a growing body of evidence has highlighted epigenetic changes, particularly the altered expression of microRNAs (miRNAs), as a critical molecular mechanism to sustain T-ALL. The immune response is emerging as key factor in the complex multistep process of cancer but the role of miRNAs in anti-leukaemia response remains elusive. In this review we analyse the available literature on miRNAs as tuners of the immune response in T-ALL, focusing on their role in Natural Killer, T, T-regulatory and Myeloid-derived suppressor cells. A better understanding of this molecular crosstalk may provide the basis for the development of potential immunotherapeutic strategies in the leukemia field.

MicroRNAs as Modulators of the Immune Response in T-Cell Acute Lymphoblastic Leukemia / Del Gaizo, M.; Sergio, I.; Lazzari, S.; Cialfi, S.; Pelullo, M.; Screpanti, I.; Felli, M. P.. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - 23:2(2022), p. 829. [10.3390/ijms23020829]

MicroRNAs as Modulators of the Immune Response in T-Cell Acute Lymphoblastic Leukemia

Del Gaizo M.;Sergio I.
Co-primo
Writing – Original Draft Preparation
;
Lazzari S.;Cialfi S.;Pelullo M.;Screpanti I.;Felli M. P.
Ultimo
Writing – Review & Editing
2022

Abstract

Acute lymphoblastic leukaemia (ALL) is an aggressive haematological tumour driven by the malignant transformation and expansion of B-cell (B-ALL) or T-cell (T-ALL) progenitors. The evolution of T-ALL pathogenesis encompasses different master developmental pathways, including the main role played by Notch in cell fate choices during tissue differentiation. Recently, a growing body of evidence has highlighted epigenetic changes, particularly the altered expression of microRNAs (miRNAs), as a critical molecular mechanism to sustain T-ALL. The immune response is emerging as key factor in the complex multistep process of cancer but the role of miRNAs in anti-leukaemia response remains elusive. In this review we analyse the available literature on miRNAs as tuners of the immune response in T-ALL, focusing on their role in Natural Killer, T, T-regulatory and Myeloid-derived suppressor cells. A better understanding of this molecular crosstalk may provide the basis for the development of potential immunotherapeutic strategies in the leukemia field.
2022
Acute lym-phoblastic leukaemia; MDSC; MicroRNA; Natural Killer cells; Notch; T and regulatory T cells
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
MicroRNAs as Modulators of the Immune Response in T-Cell Acute Lymphoblastic Leukemia / Del Gaizo, M.; Sergio, I.; Lazzari, S.; Cialfi, S.; Pelullo, M.; Screpanti, I.; Felli, M. P.. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - 23:2(2022), p. 829. [10.3390/ijms23020829]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1605213
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