Background: Elderly people are exposed to an increased load of stressful events and neuro-hormonal stimulation is a key finding in metabolic syndrome and its related disorders. Aims: To determine the role of cortisol in elderly subjects, with or without metabolic syndrome (MetS), by means of a national multicentre observational study, AGICO (AGIng and Cortisol). Methods: From 2012 to 2017, the AGICO study enrolled n.339 subjects (aged > 65), after obtaining their informed consent. The investigators assessed a cardio-metabolic panel (including electrocardiogram, carotid ultrasonography and echocardiography), the presence of MetS (on Adult Treatment Panel III criteria), a neurological examination (including brain imaging), and cortisol activity (using a consecutive collection of diurnal and nocturnal urine). Results: In the patients presenting with MetS, the standardized diurnal and nocturnal cortisol excretion rates were 210.7 ± 145.5 and 173.7 ± 118.1 (mean ± standard deviation) μg/g creatinine/12 h; in those without MetS, the standardized diurnal and nocturnal cortisol excretion rates were 188.7 ± 92.7 and 144.1 ± 82.3 μg/g creatinine/12 h, respectively (nocturnal urinary cortisol in patients with MetS versus those without MetS p = 0.05, female patients with MetS vs female patients without MetS, p < 0.025). A significant positive correlation was found between the CRP levels and both the diurnal and nocturnal urinary cortisol levels with r = 0.187 (p < 0.025) and r = 0.411 (p < 0.00000001), respectively. Discussion: The elderly patients with MetS showed a trend towards increased standardized nocturnal cortisol excretions, with particular regard to the female subjects. Conclusion: The positive correlation between cortisol excretion and low-grade inflammation suggests a common mechanism driving both hormonal and inflammatory changes.

The cortisol burden in elderly subjects with metabolic syndrome and its association with low-grade inflammation / Martocchia, A; Gallucci, M; Noale, M; Maggi, S; Cassol, M; Stefanelli, M; Postacchini, D; Proietti, A; Barbagallo, M; Dominguez, L J; Ferri, C; Desideri, G; Toussan, L; Pastore, F; Falaschi, G M; Paolisso, G; Falaschi, P. - In: AGING CLINICAL AND EXPERIMENTAL RESEARCH. - ISSN 1720-8319. - 32:7(2020), pp. 1-7. [10.1007/s40520-019-01322-3]

The cortisol burden in elderly subjects with metabolic syndrome and its association with low-grade inflammation

Martocchia, A
;
Gallucci, M;Maggi, S;Stefanelli, M;Proietti, A;Toussan, L;Falaschi, G M;Falaschi, P
2020

Abstract

Background: Elderly people are exposed to an increased load of stressful events and neuro-hormonal stimulation is a key finding in metabolic syndrome and its related disorders. Aims: To determine the role of cortisol in elderly subjects, with or without metabolic syndrome (MetS), by means of a national multicentre observational study, AGICO (AGIng and Cortisol). Methods: From 2012 to 2017, the AGICO study enrolled n.339 subjects (aged > 65), after obtaining their informed consent. The investigators assessed a cardio-metabolic panel (including electrocardiogram, carotid ultrasonography and echocardiography), the presence of MetS (on Adult Treatment Panel III criteria), a neurological examination (including brain imaging), and cortisol activity (using a consecutive collection of diurnal and nocturnal urine). Results: In the patients presenting with MetS, the standardized diurnal and nocturnal cortisol excretion rates were 210.7 ± 145.5 and 173.7 ± 118.1 (mean ± standard deviation) μg/g creatinine/12 h; in those without MetS, the standardized diurnal and nocturnal cortisol excretion rates were 188.7 ± 92.7 and 144.1 ± 82.3 μg/g creatinine/12 h, respectively (nocturnal urinary cortisol in patients with MetS versus those without MetS p = 0.05, female patients with MetS vs female patients without MetS, p < 0.025). A significant positive correlation was found between the CRP levels and both the diurnal and nocturnal urinary cortisol levels with r = 0.187 (p < 0.025) and r = 0.411 (p < 0.00000001), respectively. Discussion: The elderly patients with MetS showed a trend towards increased standardized nocturnal cortisol excretions, with particular regard to the female subjects. Conclusion: The positive correlation between cortisol excretion and low-grade inflammation suggests a common mechanism driving both hormonal and inflammatory changes.
aging; cortisol; Inflammation; metabolic syndrome; aged; aged; 80 and over; echocardiography; female; humans; hydrocortisone; inflammation; male; metabolic syndrome
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The cortisol burden in elderly subjects with metabolic syndrome and its association with low-grade inflammation / Martocchia, A; Gallucci, M; Noale, M; Maggi, S; Cassol, M; Stefanelli, M; Postacchini, D; Proietti, A; Barbagallo, M; Dominguez, L J; Ferri, C; Desideri, G; Toussan, L; Pastore, F; Falaschi, G M; Paolisso, G; Falaschi, P. - In: AGING CLINICAL AND EXPERIMENTAL RESEARCH. - ISSN 1720-8319. - 32:7(2020), pp. 1-7. [10.1007/s40520-019-01322-3]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1605169
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