The coronavirus disease 2019 (COVID-19) disrupted the healthcare system: when ‘business as usual’ is no longer possible, as intensive care units (ICUs) follow the principle of ‘capacity to benefit’ to accommodate as many COVID-19 patients requiring ventilation as possible, there is an important decrease in the organ pool [1]. The lack of ICU capacity to accommodate donors dying from different reasons than COVID-19 leads to a drastic reduction of the transplant activity, important resource to be preserved in a safe and clean environment, separated by the rest of the dedicated COVID-19 beds. There is evidence, in fact, that COVID-19 could be a nosocomial infection [2]. Furthermore, transplantation requires immunosuppression. In population at risk, the innate immune system fails to produce an adequate adaptive response, so persistent self-induced inflammation can cause mortality and mounting an early adaptive immune response may save lives [3], a concept that fails to match with the required post-transplant immunosuppression.
Kidney transplantation and the lockdown effect / Bellini, Maria Irene; Tortorici, Francesco; Capogni, Marco. - In: TRANSPLANT INTERNATIONAL. - ISSN 1432-2277. - 33:9(2020), pp. 1142-1143. [10.1111/tri.13639]
Kidney transplantation and the lockdown effect
Maria Irene Bellini
Primo
;
2020
Abstract
The coronavirus disease 2019 (COVID-19) disrupted the healthcare system: when ‘business as usual’ is no longer possible, as intensive care units (ICUs) follow the principle of ‘capacity to benefit’ to accommodate as many COVID-19 patients requiring ventilation as possible, there is an important decrease in the organ pool [1]. The lack of ICU capacity to accommodate donors dying from different reasons than COVID-19 leads to a drastic reduction of the transplant activity, important resource to be preserved in a safe and clean environment, separated by the rest of the dedicated COVID-19 beds. There is evidence, in fact, that COVID-19 could be a nosocomial infection [2]. Furthermore, transplantation requires immunosuppression. In population at risk, the innate immune system fails to produce an adequate adaptive response, so persistent self-induced inflammation can cause mortality and mounting an early adaptive immune response may save lives [3], a concept that fails to match with the required post-transplant immunosuppression.File | Dimensione | Formato | |
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