The use of immune checkpoint inhibitors (ICIs) offers new possibilities in modern treatment of many types of cancers. Few data regarding safety and efficacy of ICIs are available, and are mainly from retrospective studies and case reports rather than from clinical trials, in the context of preexisting autoimmune disease, mainly due to the risk of severe toxicity. We present an unexpected life-threatening reactivation of systemic lupus erythematosus after one dose of chemo-immunotherapy with pembrolizumab for oligometastatic non-small-cell lung cancer. We analyze data coming from the published literature in this setting and discuss the risk–benefit balance of immunotherapy in patients with preexisting severe autoimmune disease.
Systemic lupus erythematosus reactivation after chemoimmunotherapy in preexisting autoimmune disease / Spagnoletti, A.; Platania, M.; Brambilla, M.; Occhipinti, Mario; Canziani, L.; Cabras, A.; Provenzano, L.; Leone, A. G.; Ambrosini, P.; Prelaj, A.. - In: TUMORI. - ISSN 0300-8916. - (2022), p. 3008916211067565. [10.1177/03008916211067565]
Systemic lupus erythematosus reactivation after chemoimmunotherapy in preexisting autoimmune disease
Occhipinti Mario;
2022
Abstract
The use of immune checkpoint inhibitors (ICIs) offers new possibilities in modern treatment of many types of cancers. Few data regarding safety and efficacy of ICIs are available, and are mainly from retrospective studies and case reports rather than from clinical trials, in the context of preexisting autoimmune disease, mainly due to the risk of severe toxicity. We present an unexpected life-threatening reactivation of systemic lupus erythematosus after one dose of chemo-immunotherapy with pembrolizumab for oligometastatic non-small-cell lung cancer. We analyze data coming from the published literature in this setting and discuss the risk–benefit balance of immunotherapy in patients with preexisting severe autoimmune disease.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
