The present review deals with the functional roles of iodine and its metabolism. The main biological function of iodine concerns its role in the biosynthesis of thyroid hormones (THs) by the thyroid gland. In addition, however, further biological roles of iodine have emerged. Precisely, due to its significant action as scavenger of reactive oxygen species (ROS), iodine is thought to represent one of the oldest antioxidants in living organisms. Moreover, iodine oxidation to hypoiodite (IO−) has been shown to possess strong bactericidal as well as antiviral and antifungal activity. Finally, and importantly, iodine has been demonstrated to exert antineoplastic effects in human cancer cell lines. Thus, iodine, through the action of different tissue-specific peroxidases, may serve different evolutionarily conserved physiological functions that, beyond TH biosynthesis, encompass antioxidant activity and defense against pathogens and cancer progression.

Iodine: its role in thyroid hormone biosynthesis and beyond / Sorrenti, S.; Baldini, E.; Pironi, D.; Lauro, A.; D'Orazi, V.; Tartaglia, F.; Tripodi, D.; Lori, E.; Gagliardi, F.; Pratico, M.; Illuminati, G.; D'Andrea, V.; Palumbo, P.; Ulisse, S.. - In: NUTRIENTS. - ISSN 2072-6643. - 13:12(2021), p. 4469. [10.3390/nu13124469]

Iodine: its role in thyroid hormone biosynthesis and beyond

Sorrenti S.;Baldini E.;Pironi D.;Lauro A.;D'orazi V.;Tartaglia F.;Tripodi D.;Lori E.;Gagliardi F.;Illuminati G.;D'andrea V.;Palumbo P.;Ulisse S.
2021

Abstract

The present review deals with the functional roles of iodine and its metabolism. The main biological function of iodine concerns its role in the biosynthesis of thyroid hormones (THs) by the thyroid gland. In addition, however, further biological roles of iodine have emerged. Precisely, due to its significant action as scavenger of reactive oxygen species (ROS), iodine is thought to represent one of the oldest antioxidants in living organisms. Moreover, iodine oxidation to hypoiodite (IO−) has been shown to possess strong bactericidal as well as antiviral and antifungal activity. Finally, and importantly, iodine has been demonstrated to exert antineoplastic effects in human cancer cell lines. Thus, iodine, through the action of different tissue-specific peroxidases, may serve different evolutionarily conserved physiological functions that, beyond TH biosynthesis, encompass antioxidant activity and defense against pathogens and cancer progression.
2021
Antioxidants; cancer; Iodine; Iodine prophylaxis; Peroxidase; pregnancy; thyroid hormone biosynthesis; antioxidants; humans; Iodine compounds; thyroid hormones
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Iodine: its role in thyroid hormone biosynthesis and beyond / Sorrenti, S.; Baldini, E.; Pironi, D.; Lauro, A.; D'Orazi, V.; Tartaglia, F.; Tripodi, D.; Lori, E.; Gagliardi, F.; Pratico, M.; Illuminati, G.; D'Andrea, V.; Palumbo, P.; Ulisse, S.. - In: NUTRIENTS. - ISSN 2072-6643. - 13:12(2021), p. 4469. [10.3390/nu13124469]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1602602
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