This review focuses on the effects of hydrogen sulfide (H2 S) on the unique bioenergetic molecular machines in mitochondria and bacteria—the protein complexes of electron transport chains and associated enzymes. H2 S, along with nitric oxide and carbon monoxide, belongs to the class of endogenous gaseous signaling molecules. This compound plays critical roles in physiology and pathophysiology. Enzymes implicated in H2 S metabolism and physiological actions are promising targets for novel pharmaceutical agents. The biological effects of H2 S are biphasic, changing from cytoprotection to cytotoxicity through increasing the compound concentration. In mammals, H2 S enhances the activity of Fo F1-ATP (adenosine triphosphate) synthase and lactate dehydrogenase via their S-sulfhydration, thereby stimulating mitochondrial electron transport. H2 S serves as an electron donor for the mitochondrial respiratory chain via sulfide quinone oxidoreductase and cytochrome c oxidase at low H2 S levels. The latter enzyme is inhibited by high H2 S concentrations, resulting in the reversible inhibition of electron transport and ATP production in mitochondria. In the branched respiratory chain of Escherichia coli, H2 S inhibits the bo3 terminal oxidase but does not affect the alternative bd-type oxidases. Thus, in E. coli and presumably other bacteria, cytochrome bd permits respiration and cell growth in H2 S-rich environments. A complete picture of the impact of H2 S on bioenergetics is lacking, but this field is fast-moving, and active ongoing research on this topic will likely shed light on additional, yet unknown biological effects.

Impact of hydrogen sulfide on mitochondrial and bacterial bioenergetics / Borisov, V. B.; Forte, E.. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - 22:23(2021), p. 12688. [10.3390/ijms222312688]

Impact of hydrogen sulfide on mitochondrial and bacterial bioenergetics

Forte E.
2021

Abstract

This review focuses on the effects of hydrogen sulfide (H2 S) on the unique bioenergetic molecular machines in mitochondria and bacteria—the protein complexes of electron transport chains and associated enzymes. H2 S, along with nitric oxide and carbon monoxide, belongs to the class of endogenous gaseous signaling molecules. This compound plays critical roles in physiology and pathophysiology. Enzymes implicated in H2 S metabolism and physiological actions are promising targets for novel pharmaceutical agents. The biological effects of H2 S are biphasic, changing from cytoprotection to cytotoxicity through increasing the compound concentration. In mammals, H2 S enhances the activity of Fo F1-ATP (adenosine triphosphate) synthase and lactate dehydrogenase via their S-sulfhydration, thereby stimulating mitochondrial electron transport. H2 S serves as an electron donor for the mitochondrial respiratory chain via sulfide quinone oxidoreductase and cytochrome c oxidase at low H2 S levels. The latter enzyme is inhibited by high H2 S concentrations, resulting in the reversible inhibition of electron transport and ATP production in mitochondria. In the branched respiratory chain of Escherichia coli, H2 S inhibits the bo3 terminal oxidase but does not affect the alternative bd-type oxidases. Thus, in E. coli and presumably other bacteria, cytochrome bd permits respiration and cell growth in H2 S-rich environments. A complete picture of the impact of H2 S on bioenergetics is lacking, but this field is fast-moving, and active ongoing research on this topic will likely shed light on additional, yet unknown biological effects.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1590815
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