: Mitochondrial diseases (MD) include an heterogenous group of systemic disorders caused by sporadic or inherited mutations in nuclear or mitochondrial DNA (mtDNA), causing impairment of oxidative phosphorylation system. Hypertrophic cardiomyopathy is the dominant pattern of cardiomyopathy in all forms of mtDNA disease, being observed in almost 40% of the patients. Dilated cardiomyopathy, left ventricular noncompaction, and conduction system disturbances have been also reported. In this article, the authors discuss the current clinical knowledge on MD, focusing on diagnosis and management of mitochondrial diseases caused by mtDNA mutations.

Cardiovascular involvement in mtDNA disease: diagnosis, management, and therapeutic options / Lioncino, Michele; Monda, Emanuele; Caiazza, Martina; Fusco, Adelaide; Cirillo, Annapaola; Dongiglio, Francesca; Simonelli, Vicenzo; Sampaolo, Simone; Ruggiero, Lucia; Scarano, Gioacchino; Pota, Vicenzo; Frisso, Giulia; Mazzaccara, Cristina; D'Amati, Giulia; Nigro, Gerardo; Russo, Maria Giovanna; Wahbi, Karim; Limongelli, Giuseppe. - In: HEART FAILURE CLINICS. - ISSN 1551-7136. - 18:1(2021), pp. 51-60. [10.1016/j.hfc.2021.07.003]

Cardiovascular involvement in mtDNA disease: diagnosis, management, and therapeutic options

D'Amati, Giulia;
2021

Abstract

: Mitochondrial diseases (MD) include an heterogenous group of systemic disorders caused by sporadic or inherited mutations in nuclear or mitochondrial DNA (mtDNA), causing impairment of oxidative phosphorylation system. Hypertrophic cardiomyopathy is the dominant pattern of cardiomyopathy in all forms of mtDNA disease, being observed in almost 40% of the patients. Dilated cardiomyopathy, left ventricular noncompaction, and conduction system disturbances have been also reported. In this article, the authors discuss the current clinical knowledge on MD, focusing on diagnosis and management of mitochondrial diseases caused by mtDNA mutations.
File allegati a questo prodotto
File Dimensione Formato  
Lioncino_Cardiovascular_2022.pdf

embargo fino al 27/10/2022

Tipologia: Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza: Creative commons
Dimensione 703.77 kB
Formato Adobe PDF
703.77 kB Adobe PDF Visualizza/Apri PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1589697
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 3
social impact