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EnglishStem cells from human exfoliated deciduous teeth (SHEDs) are considered a type of mesenchymal stem cells (MSCs) because of their unique origin from the neural crest. SHEDs can self-renewal and multi-lineage differentiation with the ability to differentiate into odontoblasts, osteoblast, chondrocytes, neuronal cells, hepatocytes, adipocytes, etc. They are emerging as an ideal source of MSCs because of their easy availability and extraordinary cell number. Ascorbic acid, or vitamin C, has many cell-based applications, such as bone regeneration, osteoblastic differentiation, or extracellular matrix production. It also impacts stem cell plasticity and the ability to sustain pluripotent activity. In this study, we evaluate the effects of ascorbic acid on stemness, paracrine secretion, and differentiation into osteoblast, chondrocytes, and adipocytes. SHEDs displayed enhanced multifaceted activity, which may have applications in regenerative therapy.
Effect of ascorbic acid on differentiation, secretome and stemness of stem cells from human exfoliated deciduous tooth (SHEDs) / Bhandi, S.; Alkahtani, A.; Mashyakhy, M.; Abumelha, A. S.; Albar, N. H. M.; Renugalakshmi, A.; Alkahtany, M. F.; Robaian, A.; Almeslet, A. S.; Patil, V. R.; Varadarajan, S.; Balaji, T. M.; Reda, R.; Testarelli, L.; Patil, S.. - In: JOURNAL OF PERSONALIZED MEDICINE. - ISSN 2075-4426. - 11:7(2021). [10.3390/jpm11070589]
| Titolo: | Effect of ascorbic acid on differentiation, secretome and stemness of stem cells from human exfoliated deciduous tooth (SHEDs) | |
| Autori: | ||
| Data di pubblicazione: | 2021 | |
| Rivista: | ||
| Citazione: | Effect of ascorbic acid on differentiation, secretome and stemness of stem cells from human exfoliated deciduous tooth (SHEDs) / Bhandi, S.; Alkahtani, A.; Mashyakhy, M.; Abumelha, A. S.; Albar, N. H. M.; Renugalakshmi, A.; Alkahtany, M. F.; Robaian, A.; Almeslet, A. S.; Patil, V. R.; Varadarajan, S.; Balaji, T. M.; Reda, R.; Testarelli, L.; Patil, S.. - In: JOURNAL OF PERSONALIZED MEDICINE. - ISSN 2075-4426. - 11:7(2021). [10.3390/jpm11070589] | |
| Handle: | http://hdl.handle.net/11573/1587856 | |
| Appartiene alla tipologia: | 01a Articolo in rivista |
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| File | Note | Tipologia | Licenza | |
|---|---|---|---|---|
| Bhandi_Effect-of-Ascorbic_2021.pdf | https://www.mdpi.com/2075-4426/11/7/589 | Versione editoriale (versione pubblicata con il layout dell'editore) |  | Open Access Visualizza/Apri |
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