Glaucoma is considered a neurodegenerative disease due to its pathophysiology and is one of the most common causes of vision loss worldwide. The treatment of glaucoma is essentially based on the reduction of IOP, through pharmacological therapies. The iPSCs enabling autologous transplantation and have the advantage of not generating immune-mediated rejection in the host, that iPSC can be induced to differentiate into a cell type that resembles to TM cells, The iPSC-TM. The data demonstrate that intraocular injection of iPSC-TM prevents the IOP elevation, the aqueous humor outflow reduction and results in preservation of Retinal Ganglion Cell (RGC) density in vivo mice models

Regeneration of trabecular meshwork in primary open angle glaucoma by stem cell therapy / Vingolo, Enzo Maria; Chabib, Ayoub. - In: TRANSPLANT RESEARCH AND RISK MANAGEMENT. - ISSN 1179-1616. - 12:(2021), pp. 90-91.

Regeneration of trabecular meshwork in primary open angle glaucoma by stem cell therapy

enzo maria vingolo
Primo
Conceptualization
;
Ayoub Chabib
Ultimo
Writing – Original Draft Preparation
2021

Abstract

Glaucoma is considered a neurodegenerative disease due to its pathophysiology and is one of the most common causes of vision loss worldwide. The treatment of glaucoma is essentially based on the reduction of IOP, through pharmacological therapies. The iPSCs enabling autologous transplantation and have the advantage of not generating immune-mediated rejection in the host, that iPSC can be induced to differentiate into a cell type that resembles to TM cells, The iPSC-TM. The data demonstrate that intraocular injection of iPSC-TM prevents the IOP elevation, the aqueous humor outflow reduction and results in preservation of Retinal Ganglion Cell (RGC) density in vivo mice models
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1587762
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