Insomnia (ID) is the most common sleep disorder; however pathogenetic mechanisms underlying ID symptoms are not fully understood. Adopting a multifactorial view and considering ID a condition that involves interregional neuronal coordination would be useful to understand the ID pathophysiology. Functional connectivity (FC) may help to shed light on functional processes and neural correlates underlying ID symptoms. Despite a growing number of studies assessing FC anomalies, insight into ID pathophysiology is still fragmentary. This systematic review aims to search empirical evidence regarding FC changes in ID during resting-state. Thirty-one studies involving 1052 ID participants met the inclusion criteria for this review. Results suggested several associations between ID symptoms and impaired intra- and inter-hemispheric interactions of principal resting-state networks. Overall, evidence supported the hypothesis that a disrupted organization of the brain functional connectome characterizes ID, resulting in a decline in sleep, cognition, emotion, and memory. However, the wide methodological heterogeneity between reviewed studies and limitations in terms of study protocols and statistical approaches raised from this systematic review, makes it difficult to provide a univocal framework of ID pathophysiology. Future researches in this field should lead towards shared and rigorous search designs to ensure solid research evidence in the ID pathophysiology.

Functional connectivity changes in insomnia disorder: a systematic review / Fasiello, Elisabetta; Gorgoni, Maurizio; Scarpelli, Serena; Alfonsi, Valentina; Strambi, Luigi Ferini; De Gennaro, Luigi. - In: SLEEP MEDICINE REVIEWS. - ISSN 1087-0792. - 61:(2021). [10.1016/j.smrv.2021.101569]

Functional connectivity changes in insomnia disorder: a systematic review

Fasiello, Elisabetta;Gorgoni, Maurizio;Scarpelli, Serena;Alfonsi, Valentina;De Gennaro, Luigi
2021

Abstract

Insomnia (ID) is the most common sleep disorder; however pathogenetic mechanisms underlying ID symptoms are not fully understood. Adopting a multifactorial view and considering ID a condition that involves interregional neuronal coordination would be useful to understand the ID pathophysiology. Functional connectivity (FC) may help to shed light on functional processes and neural correlates underlying ID symptoms. Despite a growing number of studies assessing FC anomalies, insight into ID pathophysiology is still fragmentary. This systematic review aims to search empirical evidence regarding FC changes in ID during resting-state. Thirty-one studies involving 1052 ID participants met the inclusion criteria for this review. Results suggested several associations between ID symptoms and impaired intra- and inter-hemispheric interactions of principal resting-state networks. Overall, evidence supported the hypothesis that a disrupted organization of the brain functional connectome characterizes ID, resulting in a decline in sleep, cognition, emotion, and memory. However, the wide methodological heterogeneity between reviewed studies and limitations in terms of study protocols and statistical approaches raised from this systematic review, makes it difficult to provide a univocal framework of ID pathophysiology. Future researches in this field should lead towards shared and rigorous search designs to ensure solid research evidence in the ID pathophysiology.
2021
insomnia disorder; functional connectivity; hyperarousal; fMRI; RSNs; nodebased analyses; voxel-based analyses
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Functional connectivity changes in insomnia disorder: a systematic review / Fasiello, Elisabetta; Gorgoni, Maurizio; Scarpelli, Serena; Alfonsi, Valentina; Strambi, Luigi Ferini; De Gennaro, Luigi. - In: SLEEP MEDICINE REVIEWS. - ISSN 1087-0792. - 61:(2021). [10.1016/j.smrv.2021.101569]
File allegati a questo prodotto
File Dimensione Formato  
Fasiello_postprint_Functional-connectivity_2022.pdf

Open Access dal 12/11/2022

Tipologia: Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza: Creative commons
Dimensione 1.2 MB
Formato Adobe PDF
1.2 MB Adobe PDF
Fasiello_Functional-connectivity_2022.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 751.98 kB
Formato Adobe PDF
751.98 kB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1587569
Citazioni
  • ???jsp.display-item.citation.pmc??? 21
  • Scopus 37
  • ???jsp.display-item.citation.isi??? 33
social impact