In the last two decades studies of lymphoscintigraphy imaging in lymphatic mapping reported an extreme heterogeneity of skin lymphatic drainage of some skin area, in contrast with previ-ous scientific literature. The aim of this study was to investigate the presence of any correlations between the topographical location of cutaneous melanoma and the topographical location of sentinel lymph nodes. Data from 165 patients undergoing sentinel lymph node biopsy between January 2013 and May 2021 were analyzed, demonstrating that melanomas in the Lumbar region presented a significant more heterogeneous drainage by site than those in the Scapular region (p < 0.01) and that melanomas in the Subscapular region were significantly more heterogeneous by laterality (unilateral vs. bilateral) than those in the Scapular region (p < 0.05). Results of this study supported the evidence of multiple lymphatic drainage as regards the sentinel node biop-sy performed in skin melanoma located on the dorsal subscapular region and lumbar region. For this reason, the association of preoperative lymphoscintigraphy with another imaging evaluation is needed in these critical cutaneous area. Recent technical developments enabling fluorescence lymphography together with indocyanine green have significantly improved the visualization of lymphatic drainage patterns at a microscopic level. In the preoperative phase, any doubt can be resolved by associating the SPET-CT scan to lymphoscintigraphy, while during the intraoperative phase, an additional evaluation with indocyanine green can be performed in doubtful cases. The aim of the duplex lymphatic mapping (pre and/or intraoperative) is an accu-rate search of sentinel nodes, in order to reduce the rate of false negatives.

Analysis of the different lymphatic drainage patterns during sentinel lymph node biopsy for skin melanoma / Cirocchi, Roberto; Metaj, Giulio; Cicoletti, Michela; Arcangeli, Fabrizio; De Sol, Angelo; Poli, Giulia; Bruzzone, Paolo; Gioia, Sara; Anagnostou, Christos; Loreti, Fabio; Francesconi, Simona; Ricci, Linda; Elena Laurenti, Maria; Capotorti, Andrea; Artico, Marco; D'Andrea, Vito; Michael Henry, Brandon; Fedeli, Piergiorgio; Carlini., Luigi. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 10:23(2021). [10.3390/jcm10235544]

Analysis of the different lymphatic drainage patterns during sentinel lymph node biopsy for skin melanoma

Paolo Bruzzone
Writing – Review & Editing
;
Marco Artico
Writing – Review & Editing
;
Vito D'Andrea
Data Curation
;
2021

Abstract

In the last two decades studies of lymphoscintigraphy imaging in lymphatic mapping reported an extreme heterogeneity of skin lymphatic drainage of some skin area, in contrast with previ-ous scientific literature. The aim of this study was to investigate the presence of any correlations between the topographical location of cutaneous melanoma and the topographical location of sentinel lymph nodes. Data from 165 patients undergoing sentinel lymph node biopsy between January 2013 and May 2021 were analyzed, demonstrating that melanomas in the Lumbar region presented a significant more heterogeneous drainage by site than those in the Scapular region (p < 0.01) and that melanomas in the Subscapular region were significantly more heterogeneous by laterality (unilateral vs. bilateral) than those in the Scapular region (p < 0.05). Results of this study supported the evidence of multiple lymphatic drainage as regards the sentinel node biop-sy performed in skin melanoma located on the dorsal subscapular region and lumbar region. For this reason, the association of preoperative lymphoscintigraphy with another imaging evaluation is needed in these critical cutaneous area. Recent technical developments enabling fluorescence lymphography together with indocyanine green have significantly improved the visualization of lymphatic drainage patterns at a microscopic level. In the preoperative phase, any doubt can be resolved by associating the SPET-CT scan to lymphoscintigraphy, while during the intraoperative phase, an additional evaluation with indocyanine green can be performed in doubtful cases. The aim of the duplex lymphatic mapping (pre and/or intraoperative) is an accu-rate search of sentinel nodes, in order to reduce the rate of false negatives.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1587394
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