Autophagy and the lysosomal system, together referred to as the autophagolysosomal system, is a cellular quality control network which maintains cellular health and homeostasis by removing cellular waste including protein aggregates, damaged organelles, and invading pathogens. As such, the autophagolysosomal system has roles in a variety of pathophysiological disorders, including cancer, neurological disorders, immune- and inflammation-related diseases, and metabolic alterations, among others. The autophagolysosomal system is controlled by TFEB, a master transcriptional regulator driving the expression of multiple genes, including autophagoly sosomal components. Importantly, Reactive Oxygen Species (ROS) production and control are key aspects of the physiopathological roles of the autophagolysosomal system, and may hold a key for synergistic therapeutic interventions. In this study, we reviewed our current knowledge on the biology and physiopathology of the autophagolysosomal system, and its potential for therapeutic intervention in cancer.

Autophagy and the lysosomal system in cancer / Kumar, Suresh; Sánchez-Álvarez, Miguel; Lolo, Fidel-Nicolás; Trionfetti, Flavia; Strippoli, Raffaele; Marco, Cordani. - In: CELLS. - ISSN 2073-4409. - 10:10(2021). [10.3390/cells10102752]

Autophagy and the lysosomal system in cancer

Trionfetti Flavia;Raffaele Strippoli
;
2021

Abstract

Autophagy and the lysosomal system, together referred to as the autophagolysosomal system, is a cellular quality control network which maintains cellular health and homeostasis by removing cellular waste including protein aggregates, damaged organelles, and invading pathogens. As such, the autophagolysosomal system has roles in a variety of pathophysiological disorders, including cancer, neurological disorders, immune- and inflammation-related diseases, and metabolic alterations, among others. The autophagolysosomal system is controlled by TFEB, a master transcriptional regulator driving the expression of multiple genes, including autophagoly sosomal components. Importantly, Reactive Oxygen Species (ROS) production and control are key aspects of the physiopathological roles of the autophagolysosomal system, and may hold a key for synergistic therapeutic interventions. In this study, we reviewed our current knowledge on the biology and physiopathology of the autophagolysosomal system, and its potential for therapeutic intervention in cancer.
2021
AMPK; TFEB; autophagy; cancer; lysosomes; mTOR; nanoparticles
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Autophagy and the lysosomal system in cancer / Kumar, Suresh; Sánchez-Álvarez, Miguel; Lolo, Fidel-Nicolás; Trionfetti, Flavia; Strippoli, Raffaele; Marco, Cordani. - In: CELLS. - ISSN 2073-4409. - 10:10(2021). [10.3390/cells10102752]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1586405
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