Context: Experimental studies on Klinefelter syndrome (KS) reported increased intratesticular testosterone (T) levels coexisting with reduced circulating levels. Abnormalities in testicular microcirculation have been claimed; however, no studies investigated in vivo testicular blood flow dynamics in humans with KS. Objective: To analyze the testicular microcirculation in KS by contrast-enhanced ultrasonography (CEUS) and correlate vascular parameters with endocrine function. Design and Setting: Prospective study. University setting. Patients: Sixty-eight testicular scans, 34 testes from 19 T-naïve subjects with KS and 34 testes from age-matched eugonadal men (control) who underwent CEUS for incidental nonpalpable testicular lesions. Main Outcomes: CEUS kinetic parameters. Results: CEUS revealed slower testicular perfusion kinetics in subjects with KS than in age-matched controls. Specifically, the wash-in time (P = 0.018), mean transit time (P = 0.035), time to peak (P < 0.001), and wash-out time (P = 0.004) were all prolonged.Faster testicular blood flow was associated with higher total T levels. Principal component analysis and multiple linear regression analyses confirmed the findings and supported a role for reduced venous blood flow as independent predictor of total T levels. Conclusions: Testicular venous blood flow is altered in KS and independently predicts T peripheral release.

Testicular microvascular flow is altered in Klinefelter syndrome and predicts circulating testosterone / Carlomagno, Francesco; Pozza, Carlotta; Tenuta, Marta; Pofi, Riccardo; Tarani, Luigi; Sesti, Franz; Minnetti, Marianna; Gianfrilli, Daniele; Isidori, Andrea. - In: THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. - ISSN 0021-972X. - 107(2022), pp. e236-e245. [10.1210/clinem/dgab605]

Testicular microvascular flow is altered in Klinefelter syndrome and predicts circulating testosterone

Francesco Carlomagno
Co-primo
;
Carlotta Pozza
Co-primo
;
Marta Tenuta;Riccardo Pofi;Luigi Tarani;Franz Sesti;Marianna Minnetti;Daniele Gianfrilli;Andrea M Isidori
Ultimo
2022

Abstract

Context: Experimental studies on Klinefelter syndrome (KS) reported increased intratesticular testosterone (T) levels coexisting with reduced circulating levels. Abnormalities in testicular microcirculation have been claimed; however, no studies investigated in vivo testicular blood flow dynamics in humans with KS. Objective: To analyze the testicular microcirculation in KS by contrast-enhanced ultrasonography (CEUS) and correlate vascular parameters with endocrine function. Design and Setting: Prospective study. University setting. Patients: Sixty-eight testicular scans, 34 testes from 19 T-naïve subjects with KS and 34 testes from age-matched eugonadal men (control) who underwent CEUS for incidental nonpalpable testicular lesions. Main Outcomes: CEUS kinetic parameters. Results: CEUS revealed slower testicular perfusion kinetics in subjects with KS than in age-matched controls. Specifically, the wash-in time (P = 0.018), mean transit time (P = 0.035), time to peak (P < 0.001), and wash-out time (P = 0.004) were all prolonged.Faster testicular blood flow was associated with higher total T levels. Principal component analysis and multiple linear regression analyses confirmed the findings and supported a role for reduced venous blood flow as independent predictor of total T levels. Conclusions: Testicular venous blood flow is altered in KS and independently predicts T peripheral release.
2022
Klinefelter syndrome; blood flow; contrast-enhanced ultrasonography; hypogonadism; testosterone; vasculature
01 Pubblicazione su rivista::01a Articolo in rivista
Testicular microvascular flow is altered in Klinefelter syndrome and predicts circulating testosterone / Carlomagno, Francesco; Pozza, Carlotta; Tenuta, Marta; Pofi, Riccardo; Tarani, Luigi; Sesti, Franz; Minnetti, Marianna; Gianfrilli, Daniele; Isidori, Andrea. - In: THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. - ISSN 0021-972X. - 107(2022), pp. e236-e245. [10.1210/clinem/dgab605]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1584819
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