Innate lymphoid cells (ILCs) are innate lymphocytes playing essential functions in protection against microbial infections and participate in both homeostatic and pathological contexts, including tissue remodeling, cancer, and inflammatory disorders. A number of lineage-defining transcription factors concur to establish transcriptional networks which determine the identity and the activity of the distinct ILC subsets. However, the contribution of other regulatory molecules in controlling ILC development and function is also recently emerging. In this regard, noncoding RNA (ncRNAs) represent key elements of the complex regulatory network of ILC biology and host protection. ncRNAs mostly lack protein-coding potential, but they are endowed with a relevant regulatory activity in immune and nonimmune cells because of their ability to control chromatin structure, RNA stability, and/or protein synthesis. Herein, we summarize recent studies describing how distinct types of ncRNAs, mainly microRNAs, long ncRNAs, and circular RNAs, act in the context of ILC biology. In particular, we comment on how ncRNAs can exert key effects in ILCs by controlling gene expression in a cell-or state-specific manner and how this tunes distinct functional outputs in ILCs.

The regulatory activity of noncoding RNAs in ILCs / Grimaldi, A.; Pietropaolo, G.; Stabile, H.; Kosta, A.; Capuano, C.; Gismondi, A.; Santoni, A.; Sciume', G.; Fionda, C.. - In: CELLS. - ISSN 2073-4409. - 10:10(2021). [10.3390/cells10102742]

The regulatory activity of noncoding RNAs in ILCs

Grimaldi A.
Primo
;
Pietropaolo G.;Stabile H.;Kosta A.;Capuano C.;Gismondi A.;Santoni A.;Sciume' G.
Penultimo
;
Fionda C.
Ultimo
2021

Abstract

Innate lymphoid cells (ILCs) are innate lymphocytes playing essential functions in protection against microbial infections and participate in both homeostatic and pathological contexts, including tissue remodeling, cancer, and inflammatory disorders. A number of lineage-defining transcription factors concur to establish transcriptional networks which determine the identity and the activity of the distinct ILC subsets. However, the contribution of other regulatory molecules in controlling ILC development and function is also recently emerging. In this regard, noncoding RNA (ncRNAs) represent key elements of the complex regulatory network of ILC biology and host protection. ncRNAs mostly lack protein-coding potential, but they are endowed with a relevant regulatory activity in immune and nonimmune cells because of their ability to control chromatin structure, RNA stability, and/or protein synthesis. Herein, we summarize recent studies describing how distinct types of ncRNAs, mainly microRNAs, long ncRNAs, and circular RNAs, act in the context of ILC biology. In particular, we comment on how ncRNAs can exert key effects in ILCs by controlling gene expression in a cell-or state-specific manner and how this tunes distinct functional outputs in ILCs.
2021
circular RNA; innate lymphoid cells; long noncoding RNA; microRNA; noncoding RNA
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
The regulatory activity of noncoding RNAs in ILCs / Grimaldi, A.; Pietropaolo, G.; Stabile, H.; Kosta, A.; Capuano, C.; Gismondi, A.; Santoni, A.; Sciume', G.; Fionda, C.. - In: CELLS. - ISSN 2073-4409. - 10:10(2021). [10.3390/cells10102742]
File allegati a questo prodotto
File Dimensione Formato  
Grimaldi_Regulatory-activity_2021.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 793.85 kB
Formato Adobe PDF
793.85 kB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1583306
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 6
social impact