Introduction: Since cognitive impairment (CI) occurs on average in 45% of multiple sclerosis (MS) patients, the early detection of patients "at risk"of CI is important in order to promptly apply preventive strategies. The aim of the present study was to investigate the prevalence and risk factors for CI in MS patients using the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) as a screening test. Methods: During the 1-year period, CI was evaluated in 82 consecutives mild relapsing-remitting MS (EDSS ≤ 3.5) patients. Patients with 1 altered BICAMS test were defined "at risk."Both "at risk"and CI patients underwent an extensive neuropsychological battery. Results: We found that: (i) 23% had CI, (ii), 25% were "at risk"of CI, and (iii) 76% of the "at risk"patients were already impaired at the NP assessment. In particular, the Symbol Digit Modalities Test was the most compromised (70% of "at risk"and 79% of CI patients). Patients with CI had more frequently an EDSS ≥ 2.5 (p = 0.05), lower education (p = 0.05), and relapses in the last 12 months (p = 0.03). Conclusions: CI is a significant issue in MS and integration of a screening test, such as the SDMT, into routine clinical practice could be of worth to identify "at risk"patients and to promote an early therapeutic intervention.

Cognitive Performance in Relapsing-Remitting Multiple Sclerosis: At Risk or Impaired? / Altieri, M.; Fratino, M.; Maestrini, I.; DIonisi, C.; Annecca, R.; Vicenzini, E.; DI Piero, V.. - In: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS. - ISSN 1420-8008. - 49:6(2021), pp. 539-543. [10.1159/000514674]

Cognitive Performance in Relapsing-Remitting Multiple Sclerosis: At Risk or Impaired?

Altieri M.;Fratino M.;Maestrini I.;Annecca R.;Vicenzini E.;DI Piero V.
2021

Abstract

Introduction: Since cognitive impairment (CI) occurs on average in 45% of multiple sclerosis (MS) patients, the early detection of patients "at risk"of CI is important in order to promptly apply preventive strategies. The aim of the present study was to investigate the prevalence and risk factors for CI in MS patients using the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) as a screening test. Methods: During the 1-year period, CI was evaluated in 82 consecutives mild relapsing-remitting MS (EDSS ≤ 3.5) patients. Patients with 1 altered BICAMS test were defined "at risk."Both "at risk"and CI patients underwent an extensive neuropsychological battery. Results: We found that: (i) 23% had CI, (ii), 25% were "at risk"of CI, and (iii) 76% of the "at risk"patients were already impaired at the NP assessment. In particular, the Symbol Digit Modalities Test was the most compromised (70% of "at risk"and 79% of CI patients). Patients with CI had more frequently an EDSS ≥ 2.5 (p = 0.05), lower education (p = 0.05), and relapses in the last 12 months (p = 0.03). Conclusions: CI is a significant issue in MS and integration of a screening test, such as the SDMT, into routine clinical practice could be of worth to identify "at risk"patients and to promote an early therapeutic intervention.
2021
Brief International Cognitive Assessment for Multiple Sclerosis; Cognition; Cognitive impairment; Multiple sclerosis; Cognitive Dysfunction; Female; Humans; Male; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Neuropsychological Tests; Cognition
01 Pubblicazione su rivista::01a Articolo in rivista
Cognitive Performance in Relapsing-Remitting Multiple Sclerosis: At Risk or Impaired? / Altieri, M.; Fratino, M.; Maestrini, I.; DIonisi, C.; Annecca, R.; Vicenzini, E.; DI Piero, V.. - In: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS. - ISSN 1420-8008. - 49:6(2021), pp. 539-543. [10.1159/000514674]
File allegati a questo prodotto
File Dimensione Formato  
Altieri_Cognitive Performance_2021.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 138.56 kB
Formato Adobe PDF
138.56 kB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1583203
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 2
social impact