Objective: To explore whether abnormal thalamic resting-state functional connectivity (rsFC) contributes to altered sensorimotor integration and hand dexterity impairment in multiple sclerosis (MS). Methods: To evaluate sensorimotor integration, we recorded kinematic features of index finger abductions during somatosensory temporal discrimination threshold (STDT) testing in 36 patients with relapsing-remitting MS and 39 healthy controls (HC). Participants underwent a multimodal 3T structural and functional MRI protocol. Results: Patients had lower index finger abduction velocity during STDT testing compared to HC. Thalamic rsFC with the precentral and postcentral gyri, supplementary motor area (SMA), insula, and basal ganglia was higher in patients than HC. Intrathalamic rsFC and thalamic rsFC with caudate and insula bilaterally was lower in patients than HC. Finger movement velocity positively correlated with intrathalamic rsFC and negatively correlated with thalamic rsFC with the precentral and postcentral gyri, SMA, and putamen. Conclusions: Abnormal thalamic rsFC is a possible substrate for altered sensorimotor integration in MS, with high intrathalamic rsFC facilitating finger movements and increased thalamic rsFC with the basal ganglia and sensorimotor cortex contributing to motor performance deterioration. Significance: The combined study of thalamic functional connectivity and upper limb sensorimotor integration may be useful in identifying patients who can benefit from early rehabilitation to prevent upper limb motor impairment.

Altered sensorimotor integration in multiple sclerosis: A combined neurophysiological and functional MRI study / Gianni', C.; Belvisi, D.; Conte, A.; Tommasin, S.; Cortese, A.; Petsas, N.; Baione, V.; Tartaglia, M.; Millefiorini, E.; Berardelli, A.; Pantano, P.. - In: CLINICAL NEUROPHYSIOLOGY. - ISSN 1388-2457. - 132:9(2021), pp. 2191-2198. [10.1016/j.clinph.2021.05.028]

Altered sensorimotor integration in multiple sclerosis: A combined neurophysiological and functional MRI study

Gianni' C.;Belvisi D.;Conte A.;Tommasin S.;Petsas N.;Baione V.;Tartaglia M.;Millefiorini E.;Berardelli A.;Pantano P.
2021

Abstract

Objective: To explore whether abnormal thalamic resting-state functional connectivity (rsFC) contributes to altered sensorimotor integration and hand dexterity impairment in multiple sclerosis (MS). Methods: To evaluate sensorimotor integration, we recorded kinematic features of index finger abductions during somatosensory temporal discrimination threshold (STDT) testing in 36 patients with relapsing-remitting MS and 39 healthy controls (HC). Participants underwent a multimodal 3T structural and functional MRI protocol. Results: Patients had lower index finger abduction velocity during STDT testing compared to HC. Thalamic rsFC with the precentral and postcentral gyri, supplementary motor area (SMA), insula, and basal ganglia was higher in patients than HC. Intrathalamic rsFC and thalamic rsFC with caudate and insula bilaterally was lower in patients than HC. Finger movement velocity positively correlated with intrathalamic rsFC and negatively correlated with thalamic rsFC with the precentral and postcentral gyri, SMA, and putamen. Conclusions: Abnormal thalamic rsFC is a possible substrate for altered sensorimotor integration in MS, with high intrathalamic rsFC facilitating finger movements and increased thalamic rsFC with the basal ganglia and sensorimotor cortex contributing to motor performance deterioration. Significance: The combined study of thalamic functional connectivity and upper limb sensorimotor integration may be useful in identifying patients who can benefit from early rehabilitation to prevent upper limb motor impairment.
2021
Multiple sclerosis; Resting-state functional connectivity; Sensorimotor integration; Sensory gating; Thalamus; Upper limb
01 Pubblicazione su rivista::01a Articolo in rivista
Altered sensorimotor integration in multiple sclerosis: A combined neurophysiological and functional MRI study / Gianni', C.; Belvisi, D.; Conte, A.; Tommasin, S.; Cortese, A.; Petsas, N.; Baione, V.; Tartaglia, M.; Millefiorini, E.; Berardelli, A.; Pantano, P.. - In: CLINICAL NEUROPHYSIOLOGY. - ISSN 1388-2457. - 132:9(2021), pp. 2191-2198. [10.1016/j.clinph.2021.05.028]
File allegati a questo prodotto
File Dimensione Formato  
Giannì_Altered sensorimotor integration_2021.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 1.46 MB
Formato Adobe PDF
1.46 MB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1579450
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 5
  • ???jsp.display-item.citation.isi??? 4
social impact