Since the end of 2019, the medical-scientific community has been facing a terrible pandemic caused by a new airborne viral agent known as SARS-CoV2. Already in the early stages of the pandemic, following the discovery that the virus uses the ACE2 cell receptor as a molecular target to infect the cells of our body, it was hypothesized that the renin-angiotensin-aldosterone system was involved in the pathogenesis of the disease. Since then, numerous studies have been published on the subject, but the exact role of the renin-angiotensin-aldosterone system in the path-ogenesis of COVID19 is still a matter of debate. RAAS represents an important protagonist in the pathogenesis of COVID19, providing the virus with the receptor of entry into host cells and deter-mining its organotropism. Furthermore, following infection, the virus is able to cause an increase in plasma ACE2 activity, compromising the normal function of the RAAS. This dysfunction could con-tribute to the establishment of the thrombo-inflammatory state characteristic of severe forms of COVID19. Drugs targeting RAAS represent promising therapeutic options for COVID19 sufferers.

Lock, stock and barrel: role of renin-angiotensin-aldosterone system in coronavirus disease 2019 / Zanza, C.; Tassi, M. F.; Romenskaya, T.; Piccolella, F.; Abenavoli, L.; Franceschi, F.; Piccioni, A.; Ojetti, V.; Saviano, A.; Canonico, B.; Montanari, M.; Zamai, L.; Artico, M.; Robba, C.; Racca, F.; Longhitano, Y.. - In: CELLS. - ISSN 2073-4409. - 10:7(2021). [10.3390/cells10071752]

Lock, stock and barrel: role of renin-angiotensin-aldosterone system in coronavirus disease 2019

Zanza C.
Primo
;
Artico M.;
2021

Abstract

Since the end of 2019, the medical-scientific community has been facing a terrible pandemic caused by a new airborne viral agent known as SARS-CoV2. Already in the early stages of the pandemic, following the discovery that the virus uses the ACE2 cell receptor as a molecular target to infect the cells of our body, it was hypothesized that the renin-angiotensin-aldosterone system was involved in the pathogenesis of the disease. Since then, numerous studies have been published on the subject, but the exact role of the renin-angiotensin-aldosterone system in the path-ogenesis of COVID19 is still a matter of debate. RAAS represents an important protagonist in the pathogenesis of COVID19, providing the virus with the receptor of entry into host cells and deter-mining its organotropism. Furthermore, following infection, the virus is able to cause an increase in plasma ACE2 activity, compromising the normal function of the RAAS. This dysfunction could con-tribute to the establishment of the thrombo-inflammatory state characteristic of severe forms of COVID19. Drugs targeting RAAS represent promising therapeutic options for COVID19 sufferers.
File allegati a questo prodotto
File Dimensione Formato  
Zanza_Lock, Stock and Barrel_2021.pdf

accesso aperto

Note: https://www.mdpi.com/2073-4409/10/7/1752
Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 1.06 MB
Formato Adobe PDF
1.06 MB Adobe PDF Visualizza/Apri PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/1576739
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 4
social impact