Non-anastomotic biliary strictures (NAS) are a major cause of morbidity after orthotopic liver transplantation (OLT). Although ischemic injury of peribiliary glands (PBGs) and peribiliary vascular plexus (PVP) during OLT has been associated with the later development of NAS, the exact underlying mechanisms remain unclear. We hypothesized that bile ducts of patients with NAS suffer from ongoing biliary hypoxia and lack of regeneration from PBG stem/progenitor cells.

Persistent biliary hypoxia and lack of regeneration are key mechanisms in the pathogenesis of post-transplant non-anastomotic strictures / de Jong, Iris E M; Overi, Diletta; Carpino, Guido; Gouw, Annette S H; van den Heuvel, Marius C; van Kempen, Léon C; Mancone, Carmine; Onori, Paolo; Cardinale, Vincenzo; Casadei, Luca; Alvaro, Domenico; Porte, Robert J; Gaudio, Eugenio. - In: HEPATOLOGY. - ISSN 0270-9139. - (2021), pp. 1-17. [10.1002/hep.32166]

Persistent biliary hypoxia and lack of regeneration are key mechanisms in the pathogenesis of post-transplant non-anastomotic strictures

Overi, Diletta;Carpino, Guido;Mancone, Carmine;Onori, Paolo;Cardinale, Vincenzo;Casadei, Luca;Alvaro, Domenico;Gaudio, Eugenio
2021

Abstract

Non-anastomotic biliary strictures (NAS) are a major cause of morbidity after orthotopic liver transplantation (OLT). Although ischemic injury of peribiliary glands (PBGs) and peribiliary vascular plexus (PVP) during OLT has been associated with the later development of NAS, the exact underlying mechanisms remain unclear. We hypothesized that bile ducts of patients with NAS suffer from ongoing biliary hypoxia and lack of regeneration from PBG stem/progenitor cells.
2021
orthotopic liver transplantation; biliary complications; peribiliary glands; peribiliary vascular plexus; post-transplant cholangiopathy
01 Pubblicazione su rivista::01a Articolo in rivista
Persistent biliary hypoxia and lack of regeneration are key mechanisms in the pathogenesis of post-transplant non-anastomotic strictures / de Jong, Iris E M; Overi, Diletta; Carpino, Guido; Gouw, Annette S H; van den Heuvel, Marius C; van Kempen, Léon C; Mancone, Carmine; Onori, Paolo; Cardinale, Vincenzo; Casadei, Luca; Alvaro, Domenico; Porte, Robert J; Gaudio, Eugenio. - In: HEPATOLOGY. - ISSN 0270-9139. - (2021), pp. 1-17. [10.1002/hep.32166]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1574919
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