The Aurora-A kinase regulates cell division, by controlling centrosome biology and spindle assembly. Cancer cells often display elevated levels of the kinase, due to amplification of the gene locus, increased transcription or post-translational modifications. Several inhibitors of Aurora-A activity have been developed as anti-cancer agents and are under evaluation in clinical trials. Although the well-known mitotic roles of Aurora-A point at chromosomal instability, a hallmark of cancer, as a major link between Aurora-A overexpression and disease, recent evidence highlights the existence of non-mitotic functions of potential relevance. Here we focus on a nuclear-localised fraction of Aurora-A with oncogenic roles. Interestingly, this pool would identify not only non-mitotic, but also kinase-independent functions of the kinase. We review existing data in the literature and databases, examining potential links between Aurora-A stabilisation and localisation, and discuss them in the perspective of a more effective targeting of Aurora-A in cancer therapy.

Nuclear localisation of Aurora-A: its regulation and significance for Aurora-A functions in cancer / Naso, F. D.; Boi, D.; Ascanelli, C.; Pamfil, G.; Lindon, C.; Paiardini, A.; Guarguaglini, G.. - In: ONCOGENE. - ISSN 0950-9232. - 40:23(2021), pp. 3917-3928. [10.1038/s41388-021-01766-w]

Nuclear localisation of Aurora-A: its regulation and significance for Aurora-A functions in cancer

Naso F. D.
Co-primo
;
Boi D.
Co-primo
;
Pamfil G.;Paiardini A.
;
Guarguaglini G.
2021

Abstract

The Aurora-A kinase regulates cell division, by controlling centrosome biology and spindle assembly. Cancer cells often display elevated levels of the kinase, due to amplification of the gene locus, increased transcription or post-translational modifications. Several inhibitors of Aurora-A activity have been developed as anti-cancer agents and are under evaluation in clinical trials. Although the well-known mitotic roles of Aurora-A point at chromosomal instability, a hallmark of cancer, as a major link between Aurora-A overexpression and disease, recent evidence highlights the existence of non-mitotic functions of potential relevance. Here we focus on a nuclear-localised fraction of Aurora-A with oncogenic roles. Interestingly, this pool would identify not only non-mitotic, but also kinase-independent functions of the kinase. We review existing data in the literature and databases, examining potential links between Aurora-A stabilisation and localisation, and discuss them in the perspective of a more effective targeting of Aurora-A in cancer therapy.
2021
Aurora-A kinase; cancer; small molecule inhibitors; nuclear localisation
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Nuclear localisation of Aurora-A: its regulation and significance for Aurora-A functions in cancer / Naso, F. D.; Boi, D.; Ascanelli, C.; Pamfil, G.; Lindon, C.; Paiardini, A.; Guarguaglini, G.. - In: ONCOGENE. - ISSN 0950-9232. - 40:23(2021), pp. 3917-3928. [10.1038/s41388-021-01766-w]
File allegati a questo prodotto
File Dimensione Formato  
Naso_NuclearLocalisation_2021.pdf

accesso aperto

Note: https://doi.org/10.1038/s41388-021-01766-w
Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 1.7 MB
Formato Adobe PDF
1.7 MB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1574100
Citazioni
  • ???jsp.display-item.citation.pmc??? 14
  • Scopus 22
  • ???jsp.display-item.citation.isi??? 20
social impact