Background: Vascular calcification (VC) is a marker of cardiovascular (CV) disease and various methods allow for presence and extension assessment in different arterial districts. Nevertheless, it is currently unclear which one of these methods for VC evaluation best predict outcome and if this piece of information adds to the predictive value of traditional CV risk factors in patients receiving hemodialysis (HD). Methods: data of 184 of the 466 patients followed in the Independent study (NCT00710788) were post hoc examined to assess the association three concurrent measures of vascular calcification and all-cause survival. Specifically, coronary artery calcification (CAC) was determined by the Agatston and the volume score while abdominal aorta calcification was determined by plain X-ray of the lumbar spine (Kauppila score (KS)). Survival and regression models as well as metrics of risk recalculation were used to test the association of VC and outcome beyond the Framingham risk score. Results: Middle-age (62.6(15.8) years) men (51%) and women (49%) starting HD were analyzed. Over 36 (median 36; interquartile range: 8–36) months of follow-up 69 patients expired. Each measure of VC (CAC or KS) predicted all-cause mortality independently factors commonly associated with all-cause survival (p < 0.001). Far more importantly, each measurement of VC significantly improved risk prediction and patient reclassification (p < 0.001) beyond traditional cardiovascular risk factors. Conclusions: Overall, presence and extension of VC, irrespective of the arterial site, predict risk of all-cause of death in patients starting hemodialysis. Of note, both CAC and KS increase risk stratification beyond traditional CV risk factors. However, future efforts are needed to assess whether a risk-based approach encompassing VC screening to guide HD patient management improves survival.

Predictive value of measures of vascular calcification burden and progression for risk of death in incident to dialysis patients / Bellasi, A.; Di Lullo, L.; Russo, D.; Ciarcia, R.; Magnocavallo, M.; Lavalle, C.; Ratti, C.; Fusaro, M.; Cozzolino, M.; Di Iorio, B. R.. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 10:3(2021), pp. 1-14. [10.3390/jcm10030376]

Predictive value of measures of vascular calcification burden and progression for risk of death in incident to dialysis patients

Magnocavallo M.;Lavalle C.;
2021

Abstract

Background: Vascular calcification (VC) is a marker of cardiovascular (CV) disease and various methods allow for presence and extension assessment in different arterial districts. Nevertheless, it is currently unclear which one of these methods for VC evaluation best predict outcome and if this piece of information adds to the predictive value of traditional CV risk factors in patients receiving hemodialysis (HD). Methods: data of 184 of the 466 patients followed in the Independent study (NCT00710788) were post hoc examined to assess the association three concurrent measures of vascular calcification and all-cause survival. Specifically, coronary artery calcification (CAC) was determined by the Agatston and the volume score while abdominal aorta calcification was determined by plain X-ray of the lumbar spine (Kauppila score (KS)). Survival and regression models as well as metrics of risk recalculation were used to test the association of VC and outcome beyond the Framingham risk score. Results: Middle-age (62.6(15.8) years) men (51%) and women (49%) starting HD were analyzed. Over 36 (median 36; interquartile range: 8–36) months of follow-up 69 patients expired. Each measure of VC (CAC or KS) predicted all-cause mortality independently factors commonly associated with all-cause survival (p < 0.001). Far more importantly, each measurement of VC significantly improved risk prediction and patient reclassification (p < 0.001) beyond traditional cardiovascular risk factors. Conclusions: Overall, presence and extension of VC, irrespective of the arterial site, predict risk of all-cause of death in patients starting hemodialysis. Of note, both CAC and KS increase risk stratification beyond traditional CV risk factors. However, future efforts are needed to assess whether a risk-based approach encompassing VC screening to guide HD patient management improves survival.
2021
Aorta calcification; Coronary artery calcification; Hemodialysis; Risk prediction; Vascular calcification
01 Pubblicazione su rivista::01a Articolo in rivista
Predictive value of measures of vascular calcification burden and progression for risk of death in incident to dialysis patients / Bellasi, A.; Di Lullo, L.; Russo, D.; Ciarcia, R.; Magnocavallo, M.; Lavalle, C.; Ratti, C.; Fusaro, M.; Cozzolino, M.; Di Iorio, B. R.. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 10:3(2021), pp. 1-14. [10.3390/jcm10030376]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1573508
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