The microenvironment of intrahepatic cholangiocarcinoma (iCCA) is hypovascularized, with an extensive lymphatic network. This leads to rapid cancer spread into regional lymph nodes and the liver parenchyma, precluding curative treatments. Herein, we investigated which factors released in the iCCA stroma drive the inhibition of angiogenesis and promote lymphangiogenesis.
Thrombospondin 1 and 2 along with PEDF inhibit angiogenesis and promote lymphangiogenesis in intrahepatic cholangiocarcinoma / Carpino, Guido; Cardinale, Vincenzo; Di Giamberardino, Alessandra; Overi, Diletta; Donsante, Samantha; Colasanti, Tania; Amato, Gaia; Mennini, Gianluca; Franchitto, Matteo; Conti, Fabrizio; Rossi, Massimo; Riminucci, Mara; Gaudio, Eugenio; Alvaro, Domenico; Mancone, Carmine. - In: JOURNAL OF HEPATOLOGY. - ISSN 0168-8278. - (2021). [10.1016/j.jhep.2021.07.016]
Thrombospondin 1 and 2 along with PEDF inhibit angiogenesis and promote lymphangiogenesis in intrahepatic cholangiocarcinoma
Carpino, Guido;Cardinale, VincenzoSecondo
;Di Giamberardino, Alessandra;Overi, Diletta;Donsante, Samantha;Colasanti, Tania;Mennini, Gianluca;Franchitto, Matteo;Conti, Fabrizio;Rossi, Massimo;Riminucci, Mara;Gaudio, Eugenio;Alvaro, DomenicoPenultimo
;Mancone, Carmine
Ultimo
2021
Abstract
The microenvironment of intrahepatic cholangiocarcinoma (iCCA) is hypovascularized, with an extensive lymphatic network. This leads to rapid cancer spread into regional lymph nodes and the liver parenchyma, precluding curative treatments. Herein, we investigated which factors released in the iCCA stroma drive the inhibition of angiogenesis and promote lymphangiogenesis.| File | Dimensione | Formato | |
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