The ability of the ribonucleic acid (RNA) to self-replicate, combined with a unique cocktail of chemical properties, suggested the existence of an RNA world at the origin of life. Nowadays, this hypothesis is supported by innovative high-throughput and biochemical approaches, which definitively revealed the essential contribution of RNA-mediated mechanisms to the regulation of fundamental processes of life. With the recent development of SARS-CoV-2 mRNA-based vaccines, the potential of RNA as a therapeutic tool has received public attention. Due to its intrinsic singlestranded nature and the ease with which it is synthesized in vitro, RNA indeed represents the most suitable tool for the development of drugs encompassing every type of human pathology. The maximum effectiveness and biochemical versatility is achieved in the guise of non-coding RNAs (ncRNAs), which are emerging as multifaceted regulators of tissue specification and homeostasis. Here, we report examples of coding and ncRNAs involved in muscle regeneration and discuss their potential as therapeutic tools. Small ncRNAs, such as miRNA and siRNA, have been successfully applied in the treatment of several diseases. The use of longer molecules, such as lncRNA and circRNA, is less advanced. However, based on the peculiar properties discussed below, they represent an innovative pool of RNA biomarkers and possible targets of clinical value.

Muscle regeneration and RNA: new perspectives for ancient molecules / Buonaiuto, Giulia; Desideri, Fabio; Taliani, Valeria; Ballarino, Monica. - In: CELLS. - ISSN 2073-4409. - 10:10(2021), p. 2512. [10.3390/cells10102512]

Muscle regeneration and RNA: new perspectives for ancient molecules

Buonaiuto, Giulia
Primo
Writing – Original Draft Preparation
;
Desideri, Fabio
Secondo
Writing – Original Draft Preparation
;
Taliani, Valeria
Penultimo
Resources
;
Ballarino, Monica
Ultimo
Conceptualization
2021

Abstract

The ability of the ribonucleic acid (RNA) to self-replicate, combined with a unique cocktail of chemical properties, suggested the existence of an RNA world at the origin of life. Nowadays, this hypothesis is supported by innovative high-throughput and biochemical approaches, which definitively revealed the essential contribution of RNA-mediated mechanisms to the regulation of fundamental processes of life. With the recent development of SARS-CoV-2 mRNA-based vaccines, the potential of RNA as a therapeutic tool has received public attention. Due to its intrinsic singlestranded nature and the ease with which it is synthesized in vitro, RNA indeed represents the most suitable tool for the development of drugs encompassing every type of human pathology. The maximum effectiveness and biochemical versatility is achieved in the guise of non-coding RNAs (ncRNAs), which are emerging as multifaceted regulators of tissue specification and homeostasis. Here, we report examples of coding and ncRNAs involved in muscle regeneration and discuss their potential as therapeutic tools. Small ncRNAs, such as miRNA and siRNA, have been successfully applied in the treatment of several diseases. The use of longer molecules, such as lncRNA and circRNA, is less advanced. However, based on the peculiar properties discussed below, they represent an innovative pool of RNA biomarkers and possible targets of clinical value.
2021
noncoding RNAs (ncRNAs); RNA therapeutics; skeletal muscle regeneration; cardiac regeneration
01 Pubblicazione su rivista::01a Articolo in rivista
Muscle regeneration and RNA: new perspectives for ancient molecules / Buonaiuto, Giulia; Desideri, Fabio; Taliani, Valeria; Ballarino, Monica. - In: CELLS. - ISSN 2073-4409. - 10:10(2021), p. 2512. [10.3390/cells10102512]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1570590
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