MicroRNAs are pervasive regulators of gene expression at the post-transcriptional level in metazoan, playing key roles in several physiological and pathological processes. Accordingly, these small non-coding RNAs are also involved in cancer development and progression. Further-more, miRNAs represent valuable diagnostic and prognostic biomarkers in malignancies. In the last twenty years, the role of RNA modifications in fine-tuning gene expressions at several levels has been unraveled. All RNA species may undergo post-transcriptional modifications, collectively re-ferred to as epitranscriptomic modifications, which, in many instances, affect RNA molecule prop-erties. miRNAs are not an exception, in this respect, and they have been shown to undergo several post-transcriptional modifications. In this review, we will summarize the recent findings concern-ing miRNA epitranscriptomic modifications, focusing on their potential role in cancer development and progression.
Epitranscriptomics: a new layer of microRNA regulation in cancer / De Paolis, V.; Lorefice, E.; Orecchini, E.; Carissimi, C.; Laudadio, I.; Fulci, V.. - In: CANCERS. - ISSN 2072-6694. - 13:13(2021). [10.3390/cancers13133372]
Epitranscriptomics: a new layer of microRNA regulation in cancer
De Paolis V.;Lorefice E.;Orecchini E.;Carissimi C.
;Laudadio I.
;Fulci V.
2021
Abstract
MicroRNAs are pervasive regulators of gene expression at the post-transcriptional level in metazoan, playing key roles in several physiological and pathological processes. Accordingly, these small non-coding RNAs are also involved in cancer development and progression. Further-more, miRNAs represent valuable diagnostic and prognostic biomarkers in malignancies. In the last twenty years, the role of RNA modifications in fine-tuning gene expressions at several levels has been unraveled. All RNA species may undergo post-transcriptional modifications, collectively re-ferred to as epitranscriptomic modifications, which, in many instances, affect RNA molecule prop-erties. miRNAs are not an exception, in this respect, and they have been shown to undergo several post-transcriptional modifications. In this review, we will summarize the recent findings concern-ing miRNA epitranscriptomic modifications, focusing on their potential role in cancer development and progression.| File | Dimensione | Formato | |
|---|---|---|---|
|
DePaolis_Epitranscriptomics_2021.pdf
accesso aperto
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Creative commons
Dimensione
1.12 MB
Formato
Adobe PDF
|
1.12 MB | Adobe PDF |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
