Dental implants are a widely used treatment modality for oral rehabilitation. Implant failures can be a result of many factors, with poor osseointegration being the main culprit. The present systematic review aimed to assess the effect of stem cells on the osseointegration of dental implants. An electronic search of the MEDLINE, LILACS, and EMBASE databases was conducted. We examined quantitative preclinical studies that reported on the effect of mesenchymal stem cells on bone healing after implant insertion. Eighteen studies that fulfilled the inclusion criteria were included. Various surface modification strategies, sites of placement, and cell origins were analyzed. The majority of the selected studies showed a high risk of bias, indicating that caution must be exercised in their interpretation. All the included studies reported that the stem cells used with graft material and scaffolds promoted osseointegration with higher levels of new bone formation. The mesenchymal cells attached to the implant surface facilitated the expression of bio-functionalized biomaterial surfaces, to boost bone formation and osseointegration at the bone–implant interfaces. There was a promotion of osteogenic differentiation of human mesenchymal cells and osseointegration of biomaterial implants, both in vitro and in vivo. These results highlight the significance of biomodified implant surfaces that can enhance osseointegration. These innovations can improve the stability and success rate of the implants used for oral rehabilitation.

Role of stem cells in augmenting dental implant osseointegration: a systematic review / Sayed, M. E.; Mugri, M. H.; Almasri, M. A.; Al-Ahmari, M. M.; Bhandi, S.; Madapusi, T. B.; Varadarajan, S.; Raj, A. T.; Reda, R.; Testarelli, L.; Patil, S.. - In: COATINGS. - ISSN 2079-6412. - 11:9(2021). [10.3390/coatings11091035]

Role of stem cells in augmenting dental implant osseointegration: a systematic review

Reda R.
Methodology
;
Testarelli L.
Penultimo
Conceptualization
;
2021

Abstract

Dental implants are a widely used treatment modality for oral rehabilitation. Implant failures can be a result of many factors, with poor osseointegration being the main culprit. The present systematic review aimed to assess the effect of stem cells on the osseointegration of dental implants. An electronic search of the MEDLINE, LILACS, and EMBASE databases was conducted. We examined quantitative preclinical studies that reported on the effect of mesenchymal stem cells on bone healing after implant insertion. Eighteen studies that fulfilled the inclusion criteria were included. Various surface modification strategies, sites of placement, and cell origins were analyzed. The majority of the selected studies showed a high risk of bias, indicating that caution must be exercised in their interpretation. All the included studies reported that the stem cells used with graft material and scaffolds promoted osseointegration with higher levels of new bone formation. The mesenchymal cells attached to the implant surface facilitated the expression of bio-functionalized biomaterial surfaces, to boost bone formation and osseointegration at the bone–implant interfaces. There was a promotion of osteogenic differentiation of human mesenchymal cells and osseointegration of biomaterial implants, both in vitro and in vivo. These results highlight the significance of biomodified implant surfaces that can enhance osseointegration. These innovations can improve the stability and success rate of the implants used for oral rehabilitation.
2021
dental implant; mesenchymal stem cells; osseointegration; stem cells
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Role of stem cells in augmenting dental implant osseointegration: a systematic review / Sayed, M. E.; Mugri, M. H.; Almasri, M. A.; Al-Ahmari, M. M.; Bhandi, S.; Madapusi, T. B.; Varadarajan, S.; Raj, A. T.; Reda, R.; Testarelli, L.; Patil, S.. - In: COATINGS. - ISSN 2079-6412. - 11:9(2021). [10.3390/coatings11091035]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1568153
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