microRNAs (miRNAs) are emerging as relevant molecules in cancer development and progres-sion. MiRNAs add a post-transcriptional level of control to the regulation of gene expression. The deregulation of miRNA expression results in changing the molecular circuitry in which miRNAs are involved, leading to alterations of cell fate determination. In this review, we de-scribe the miRNAs that are emerging as innovative molecular biomarkers from liquid biopsies, not only for diagnosis, but also for post-surgery management in cancer. We focus our attention on renal cell carcinoma, in particular highlighting the crucial role of circulating miRNAs in clear cell renal cell carcinoma (ccRCC) management. In addition, the functional deregulation of miR-NA expression in ccRCC is also discussed, to underline the contribution of miRNAs to ccRCC development and progression, which may be relevant for the identification and design of inno-vative clinical strategies against this tumor.

Circulating microRNAs from the molecular mechanisms to clinical biomarkers. A focus on the clear cell renal cell carcinoma / Tito, Claudia; De Falco, Elena; Rosa, Paolo; Iaiza, Alessia; Fazi, Francesco; Petrozza, Vincenzo; Calogero, Antonella. - In: GENES. - ISSN 2073-4425. - 12:8(2021). [10.3390/genes12081154]

Circulating microRNAs from the molecular mechanisms to clinical biomarkers. A focus on the clear cell renal cell carcinoma

Tito, Claudia
Co-primo
;
De Falco, Elena
Co-primo
;
Rosa, Paolo;Iaiza, Alessia;Fazi, Francesco;Petrozza, Vincenzo;Calogero, Antonella
2021

Abstract

microRNAs (miRNAs) are emerging as relevant molecules in cancer development and progres-sion. MiRNAs add a post-transcriptional level of control to the regulation of gene expression. The deregulation of miRNA expression results in changing the molecular circuitry in which miRNAs are involved, leading to alterations of cell fate determination. In this review, we de-scribe the miRNAs that are emerging as innovative molecular biomarkers from liquid biopsies, not only for diagnosis, but also for post-surgery management in cancer. We focus our attention on renal cell carcinoma, in particular highlighting the crucial role of circulating miRNAs in clear cell renal cell carcinoma (ccRCC) management. In addition, the functional deregulation of miR-NA expression in ccRCC is also discussed, to underline the contribution of miRNAs to ccRCC development and progression, which may be relevant for the identification and design of inno-vative clinical strategies against this tumor.
2021
circulating miRNAs; biomarkers; ccRCC; liquid biopsies
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Circulating microRNAs from the molecular mechanisms to clinical biomarkers. A focus on the clear cell renal cell carcinoma / Tito, Claudia; De Falco, Elena; Rosa, Paolo; Iaiza, Alessia; Fazi, Francesco; Petrozza, Vincenzo; Calogero, Antonella. - In: GENES. - ISSN 2073-4425. - 12:8(2021). [10.3390/genes12081154]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1567117
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