We evaluated the effect of DMTs on Covid-19 severity in patients with MS, with a pooled-analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid-19 severity was assessed by multivariate ordinal-logistic models and pooled by a fixed-effect meta-analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti-CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39–3.02, p < 0.001) with Covid-19 severity, whereas interferon indicated a decreased risk (OR = 0.42, 95%CI = 0.18–0.99, p = 0.047). This pooled-analysis confirms an increased risk of severe Covid-19 in patients on anti-CD20 therapies and supports the protective role of interferon.
DMTs and Covid-19 severity in MS. a pooled analysis from Italy and France / Sormani, M.P., Salvetti, M., Labauge, P., Schiavetti, I., Zephir, H., Carmisciano, L., Bensa, C., De Rossi, N., Pelletier, J., Cordioli, C., Vukusic, S., Moiola, L., Kerschen, P., Radaelli, M., Theaudin, M., Immovilli, P., Casez, O., Capobianco, M., Ciron, J., Trojano, M., et al.. - In: ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY. - ISSN 2328-9503. - 8:8(2021), pp. 1738-1744. [10.1002/acn3.51408]
DMTs and Covid-19 severity in MS. a pooled analysis from Italy and France
Salvetti M.;
2021
Abstract
We evaluated the effect of DMTs on Covid-19 severity in patients with MS, with a pooled-analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid-19 severity was assessed by multivariate ordinal-logistic models and pooled by a fixed-effect meta-analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti-CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39–3.02, p < 0.001) with Covid-19 severity, whereas interferon indicated a decreased risk (OR = 0.42, 95%CI = 0.18–0.99, p = 0.047). This pooled-analysis confirms an increased risk of severe Covid-19 in patients on anti-CD20 therapies and supports the protective role of interferon.| File | Dimensione | Formato | |
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Sormani_DMTsCovid-19-severity_2021.pdf
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Sormani_Affiliation_DMTsCovid-19-severity_2021.pdf
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