Background: our aim was to assess the diagnostic performance and clinical impact of18F-FDG PET/CT in patients with differentiated thyroid carcinoma (DTC), previously treated with surgery and radioiodine therapy (RAI). Methods: patients subjected to18F-FDG PET/CT for suspected DTC recurrence in three Italian nuclear medicine units were evaluated. Two different clinical settings were identified: clinical setting 1 included patients (n = 40) that were enrolled according to the American Thyroid Association guidelines (i.e., negative1311-WBS and Tg level > 10 ng/mL); and clinical setting 2, that encompassed subjects (n = 26) with serum Tg ≤ 10 ng/mL but morphological findings suspected of relapse. PET/CT’s impact was scored as significant if it provided an indication for surgery, or led to a novel therapeutic decision. Results: In total, 51/66 patients (77.3%) were18F-FDG positive, while 15 (22.7%) were negative. PET/CT showed an overall sensitivity and specificity of 84.4% and 75%, respectively. Sensitivity was higher in clinical setting 1 (89.1%) as compared to clinical setting 2 (76.1%), although this difference was not statistically significant (p = 0.83). PET/CT influenced clinical management in 28 cases (42.4%), without a significant difference between the 2 groups of patients (p = 0.6). Conclusions: our preliminary data, although limited by the retrospective nature of the study and possible selection bias, suggest that 18 F-FDG PET/CT may be utilized for the detection of DTC recurrence in different clinical settings, with a meaningful impact on clinical management.

Usefulness of pet/ct with18f-fdg in patients with differentiated thyroid carcinoma after radioiodine therapy: an italian multicenter study / Filippi, L.; Frantellizzi, V.; Monari, F.; Rizzini, E. L.; Tabacchi, E.; Pirisino, R.; Marongiu, A.; Nuvoli, S.; Bagni, O.; De Vincentis, G.; Schillaci, O.; Spanu, A.. - In: DIAGNOSTICS. - ISSN 2075-4418. - 11:7(2021). [10.3390/diagnostics11071264]

Usefulness of pet/ct with18f-fdg in patients with differentiated thyroid carcinoma after radioiodine therapy: an italian multicenter study

Frantellizzi V.
Secondo
;
Pirisino R.;De Vincentis G.;
2021

Abstract

Background: our aim was to assess the diagnostic performance and clinical impact of18F-FDG PET/CT in patients with differentiated thyroid carcinoma (DTC), previously treated with surgery and radioiodine therapy (RAI). Methods: patients subjected to18F-FDG PET/CT for suspected DTC recurrence in three Italian nuclear medicine units were evaluated. Two different clinical settings were identified: clinical setting 1 included patients (n = 40) that were enrolled according to the American Thyroid Association guidelines (i.e., negative1311-WBS and Tg level > 10 ng/mL); and clinical setting 2, that encompassed subjects (n = 26) with serum Tg ≤ 10 ng/mL but morphological findings suspected of relapse. PET/CT’s impact was scored as significant if it provided an indication for surgery, or led to a novel therapeutic decision. Results: In total, 51/66 patients (77.3%) were18F-FDG positive, while 15 (22.7%) were negative. PET/CT showed an overall sensitivity and specificity of 84.4% and 75%, respectively. Sensitivity was higher in clinical setting 1 (89.1%) as compared to clinical setting 2 (76.1%), although this difference was not statistically significant (p = 0.83). PET/CT influenced clinical management in 28 cases (42.4%), without a significant difference between the 2 groups of patients (p = 0.6). Conclusions: our preliminary data, although limited by the retrospective nature of the study and possible selection bias, suggest that 18 F-FDG PET/CT may be utilized for the detection of DTC recurrence in different clinical settings, with a meaningful impact on clinical management.
2021
18; F-FDG; differentiated thyroid carcinoma; oncology; positron emission computed tomography; precision medicine
01 Pubblicazione su rivista::01a Articolo in rivista
Usefulness of pet/ct with18f-fdg in patients with differentiated thyroid carcinoma after radioiodine therapy: an italian multicenter study / Filippi, L.; Frantellizzi, V.; Monari, F.; Rizzini, E. L.; Tabacchi, E.; Pirisino, R.; Marongiu, A.; Nuvoli, S.; Bagni, O.; De Vincentis, G.; Schillaci, O.; Spanu, A.. - In: DIAGNOSTICS. - ISSN 2075-4418. - 11:7(2021). [10.3390/diagnostics11071264]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1564799
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