Lipoprotein disorders are a major risk factor for atherosclerotic neuro-cardiovascular disease (ACVD) and are heavily influenced by lifestyle, including alcohol drinking. Moderate drinkers have a lower ACVD risk than abstainers because of their higher levels of high-density lipoprotein (HDL) cholesterol, an important protective factor against ACVD. On the contrary, heavy drinking increases ACVD risk. According to a large literature body, ethanol intoxication modifies lipid serum profile and induces endothelial dysfunction. Single nucleotide polymorphisms may influence the relationship between alcohol drinking, HDL cholesterol level, and atherosclerotic risk. The risk of ACVD in heavy drinkers seems enhanced in patients with apolipoprotein E4 allele, interleukin-6-174 polymorphism, and cholesteryl ester transfer protein TaqIB polymorphism. Apolipoprotein E4 is a known risk factor for ACVD, while apolipoprotein E2 has mixed effects. Therefore, even if a "protective role" may be attributed to moderate drinking, this effect cannot be extended to everyone.

Alcohol drinking, apolipoprotein polymorphisms and the risk of cardiovascular diseases / Ceci, Flavio Maria; Ceccanti, Mauro; Petrella, Carla; Vitali, Mario; Messina, Marisa Patrizia; N Chaldakov, George; Greco, Antonio; Ralli, Massimo; Lucarelli, Marco; Angeloni, Antonio; Fiore, Marco; Ferraguti, Giampiero. - In: CURRENT NEUROVASCULAR RESEARCH. - ISSN 1567-2026. - 18:1(2021), pp. 150-161. [10.2174/1567202618666210406123503]

Alcohol drinking, apolipoprotein polymorphisms and the risk of cardiovascular diseases

Flavio Maria Ceci
Primo
;
Mauro Ceccanti
Secondo
;
Marisa Patrizia Messina;Antonio Greco;Massimo Ralli;Marco Lucarelli;Antonio Angeloni;Giampiero Ferraguti
Ultimo
2021

Abstract

Lipoprotein disorders are a major risk factor for atherosclerotic neuro-cardiovascular disease (ACVD) and are heavily influenced by lifestyle, including alcohol drinking. Moderate drinkers have a lower ACVD risk than abstainers because of their higher levels of high-density lipoprotein (HDL) cholesterol, an important protective factor against ACVD. On the contrary, heavy drinking increases ACVD risk. According to a large literature body, ethanol intoxication modifies lipid serum profile and induces endothelial dysfunction. Single nucleotide polymorphisms may influence the relationship between alcohol drinking, HDL cholesterol level, and atherosclerotic risk. The risk of ACVD in heavy drinkers seems enhanced in patients with apolipoprotein E4 allele, interleukin-6-174 polymorphism, and cholesteryl ester transfer protein TaqIB polymorphism. Apolipoprotein E4 is a known risk factor for ACVD, while apolipoprotein E2 has mixed effects. Therefore, even if a "protective role" may be attributed to moderate drinking, this effect cannot be extended to everyone.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1563624
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