Introduction. Dermatomyositis (DM) is an idiopathic inflammatory myopathy (IIM) mainly characterized by subacute muscle weakness and skin rash sometimes associated with malignancy. Case Presentation. A 61-year-old female was admitted to our hospital because of progressive proximal muscular weakness, heliotropic rash and left breast rash. Muscle biopsy findings were consistent with dermatomyositis (DM). A full panel of myositis associated (MAA) and specific antibodies (MSA) revealed the presence of anti-nuclear antibodies (1:160, speckled), Anti-Ro52 and anti TIF1-gamma antibodies. A whole body Computed Tomography Scan showed three left mammary nodules and homolateral axillary lymphadenopathy. The breast biopsy confirmed the diagnosis of ductal carcinoma. Patient was initiated to neoadjuvant chemotherapy followed by surgery for cancer, and corticosteroid and intravenous immunoglobulins for DM with a complete resolution of muscle weakness and pathological complete response of breast cancer. Discussion and conclusion. Similar cases in literature are commonly referred to a first-line surgery and the role of neoadjuvant chemotherapy is debatable.

A Case of Pathological Complete Response and Resolution of Dermatomyositis Following Neoadjuvant Chemotherapy in HER2-Positive Early Breast Cancer / Piras, Marta; Panebianco, Martina; Garibaldi, Matteo; Roberto, Michela; Merlonghi, Gioia; Pellegrini, Patrizia; Marchetti, Paolo. - In: CURRENT ONCOLOGY. - ISSN 1718-7729. - 28:3(2021), pp. 1957-1961. [10.3390/curroncol28030182]

A Case of Pathological Complete Response and Resolution of Dermatomyositis Following Neoadjuvant Chemotherapy in HER2-Positive Early Breast Cancer

Piras, Marta;Panebianco, Martina;Garibaldi, Matteo;Roberto, Michela
;
Merlonghi, Gioia;Pellegrini, Patrizia;Marchetti, Paolo
2021

Abstract

Introduction. Dermatomyositis (DM) is an idiopathic inflammatory myopathy (IIM) mainly characterized by subacute muscle weakness and skin rash sometimes associated with malignancy. Case Presentation. A 61-year-old female was admitted to our hospital because of progressive proximal muscular weakness, heliotropic rash and left breast rash. Muscle biopsy findings were consistent with dermatomyositis (DM). A full panel of myositis associated (MAA) and specific antibodies (MSA) revealed the presence of anti-nuclear antibodies (1:160, speckled), Anti-Ro52 and anti TIF1-gamma antibodies. A whole body Computed Tomography Scan showed three left mammary nodules and homolateral axillary lymphadenopathy. The breast biopsy confirmed the diagnosis of ductal carcinoma. Patient was initiated to neoadjuvant chemotherapy followed by surgery for cancer, and corticosteroid and intravenous immunoglobulins for DM with a complete resolution of muscle weakness and pathological complete response of breast cancer. Discussion and conclusion. Similar cases in literature are commonly referred to a first-line surgery and the role of neoadjuvant chemotherapy is debatable.
breast cancer; dermatomyositis; neoadjuvant chemotherapy; paraneoplastic; trastuzumab
01 Pubblicazione su rivista::01a Articolo in rivista
A Case of Pathological Complete Response and Resolution of Dermatomyositis Following Neoadjuvant Chemotherapy in HER2-Positive Early Breast Cancer / Piras, Marta; Panebianco, Martina; Garibaldi, Matteo; Roberto, Michela; Merlonghi, Gioia; Pellegrini, Patrizia; Marchetti, Paolo. - In: CURRENT ONCOLOGY. - ISSN 1718-7729. - 28:3(2021), pp. 1957-1961. [10.3390/curroncol28030182]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1561840
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