Background: Levodopa-induced dyskinesias are associated with thalamo-cortical disinhibition and frontal area overactivation. Neuroimaging and transcranial magnetic stimulation studies have highlighted the involvement of the right inferior frontal cortex in levodopa-induced dyskinesias. Methods: Using transcranial magnetic stimulation, we tested connectivity between the inferior frontal and contralateral motor cortex in Parkinson's disease patients with and without levodopa-induced dyskinesias compared with age-matched controls. Furthermore, in dyskinetic patients, connectivity between the inferior frontal and contralateral motor cortex was assessed before and after a single session of continuous theta-burst stimulation applied over the inferior frontal cortex. Results: Dyskinetic patients showed abnormal facilitatory connectivity between the inferior frontal and motor cortex when compared with the nondyskinetic group. Continuous theta-burst stimulation over the inferior frontal cortex eliminated such facilitatory connectivity and decreased the levodopa-induced dyskinesias that was induced by a supramaximal dose of levodopa. Conclusion: In dyskinetic patients, a weaker inhibitory cortico-cortical interaction between the inferior frontal and contralateral motor cortex could be involved in levodopa-induced dyskinesias and restored by continuous theta-burst stimulation over the inferior frontal cortex.

Altered inhibitory interaction among inferior frontal and motor cortex in l-dopa-induced dyskinesias / Ponzo, V; Picazio, S; Benussi, A; Di Lorenzo, F; Brusa, L; Caltagirone, C; Koch, G. - In: MOVEMENT DISORDERS. - ISSN 1531-8257. - (2016). [10.1002/mds.26520]

Altered inhibitory interaction among inferior frontal and motor cortex in l-dopa-induced dyskinesias

Picazio S;
2016

Abstract

Background: Levodopa-induced dyskinesias are associated with thalamo-cortical disinhibition and frontal area overactivation. Neuroimaging and transcranial magnetic stimulation studies have highlighted the involvement of the right inferior frontal cortex in levodopa-induced dyskinesias. Methods: Using transcranial magnetic stimulation, we tested connectivity between the inferior frontal and contralateral motor cortex in Parkinson's disease patients with and without levodopa-induced dyskinesias compared with age-matched controls. Furthermore, in dyskinetic patients, connectivity between the inferior frontal and contralateral motor cortex was assessed before and after a single session of continuous theta-burst stimulation applied over the inferior frontal cortex. Results: Dyskinetic patients showed abnormal facilitatory connectivity between the inferior frontal and motor cortex when compared with the nondyskinetic group. Continuous theta-burst stimulation over the inferior frontal cortex eliminated such facilitatory connectivity and decreased the levodopa-induced dyskinesias that was induced by a supramaximal dose of levodopa. Conclusion: In dyskinetic patients, a weaker inhibitory cortico-cortical interaction between the inferior frontal and contralateral motor cortex could be involved in levodopa-induced dyskinesias and restored by continuous theta-burst stimulation over the inferior frontal cortex.
2016
Parkinson's disease; connectivity; inferior frontal cortex; levodopa-induced dyskinesia; transcranial magnetic stimulation.
01 Pubblicazione su rivista::01a Articolo in rivista
Altered inhibitory interaction among inferior frontal and motor cortex in l-dopa-induced dyskinesias / Ponzo, V; Picazio, S; Benussi, A; Di Lorenzo, F; Brusa, L; Caltagirone, C; Koch, G. - In: MOVEMENT DISORDERS. - ISSN 1531-8257. - (2016). [10.1002/mds.26520]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1561364
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