Changes in the synaptic strength of neural connections are induced by repeated coupling of activity of interconnected neurons with precise timing, a phenomenon known as spike-timing-dependent plasticity (STDP). It is debated if this mechanism exists in large-scale cortical networks in humans. We combined transcranial magnetic stimulation (TMS) with concurrent electroencephalography (EEG) to directly investigate the effects of two paired associative stimulation (PAS) protocols (fronto-parietal and parieto-frontal) of pre and post-synaptic inputs within the human fronto-parietal network. We found evidence that the dorsolateral prefrontal cortex (DLPFC) has the potential to form robust STDP. Long-term potentiation/depression of TMS-evoked cortical activity is prompted after that DLPFC stimulation is followed/preceded by posterior parietal stimulation. Such bidirectional changes are paralleled by sustained increase/decrease of high-frequency oscillatory activity, likely reflecting STDP responsivity. The current findings could be important to drive plasticity of damaged cortical circuits in patients with cognitive or psychiatric disorders.

Spike-timing-dependent plasticity in the human dorso-lateral prefrontal cortex / Casula, E. P.; Pellicciari, M. C.; Picazio, S.; Caltagirone, C.; Koch, G.. - In: NEUROIMAGE. - ISSN 1053-8119. - 143:(2016), pp. 204-213. [10.1016/j.neuroimage.2016.08.060]

Spike-timing-dependent plasticity in the human dorso-lateral prefrontal cortex

Picazio S.;
2016

Abstract

Changes in the synaptic strength of neural connections are induced by repeated coupling of activity of interconnected neurons with precise timing, a phenomenon known as spike-timing-dependent plasticity (STDP). It is debated if this mechanism exists in large-scale cortical networks in humans. We combined transcranial magnetic stimulation (TMS) with concurrent electroencephalography (EEG) to directly investigate the effects of two paired associative stimulation (PAS) protocols (fronto-parietal and parieto-frontal) of pre and post-synaptic inputs within the human fronto-parietal network. We found evidence that the dorsolateral prefrontal cortex (DLPFC) has the potential to form robust STDP. Long-term potentiation/depression of TMS-evoked cortical activity is prompted after that DLPFC stimulation is followed/preceded by posterior parietal stimulation. Such bidirectional changes are paralleled by sustained increase/decrease of high-frequency oscillatory activity, likely reflecting STDP responsivity. The current findings could be important to drive plasticity of damaged cortical circuits in patients with cognitive or psychiatric disorders.
2016
DLPFC; EEG; Plasticity; STDP; TMS
01 Pubblicazione su rivista::01a Articolo in rivista
Spike-timing-dependent plasticity in the human dorso-lateral prefrontal cortex / Casula, E. P.; Pellicciari, M. C.; Picazio, S.; Caltagirone, C.; Koch, G.. - In: NEUROIMAGE. - ISSN 1053-8119. - 143:(2016), pp. 204-213. [10.1016/j.neuroimage.2016.08.060]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1561355
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