Motile cilia are widespread across the animal and plant kingdoms, displaying complex collective dynamics central to their physiology. Their coordination mechanism is not generally understood, with previous work mainly focusing on algae and protists. We study here the entrainment of cilia beat in multiciliated cells from brain ventricles. The response to controlled oscillatory external flows shows that flows at a similar frequency to the actively beating cilia can entrain cilia oscillations. We find that the hydrodynamic forces required for this entrainment strongly depend on the number of cilia per cell. Cells with few cilia (up to five) can be entrained at flows comparable to cilia-driven flows, in contrast with what was recently observed in Chlamydomonas. Experimental trends are quantitatively described by a model that accounts for hydrodynamic screening of packed cilia and the chemomechanical energy efficiency of the flagellar beat. Simulations of a minimal model of cilia interacting hydrodynamically show the same trends observed in cilia.

Entrainment of mammalian motile cilia in the brain with hydrodynamic forces / Pellicciotta, N.; Hamilton, E.; Kotar, J.; Faucourt, M.; Delgehyr, N.; Spassky, N.; Cicuta, P.. - In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. - ISSN 0027-8424. - 117:15(2020), pp. 8315-8325. [10.1073/pnas.1910065117]

Entrainment of mammalian motile cilia in the brain with hydrodynamic forces

Pellicciotta N.;Cicuta P.
2020

Abstract

Motile cilia are widespread across the animal and plant kingdoms, displaying complex collective dynamics central to their physiology. Their coordination mechanism is not generally understood, with previous work mainly focusing on algae and protists. We study here the entrainment of cilia beat in multiciliated cells from brain ventricles. The response to controlled oscillatory external flows shows that flows at a similar frequency to the actively beating cilia can entrain cilia oscillations. We find that the hydrodynamic forces required for this entrainment strongly depend on the number of cilia per cell. Cells with few cilia (up to five) can be entrained at flows comparable to cilia-driven flows, in contrast with what was recently observed in Chlamydomonas. Experimental trends are quantitatively described by a model that accounts for hydrodynamic screening of packed cilia and the chemomechanical energy efficiency of the flagellar beat. Simulations of a minimal model of cilia interacting hydrodynamically show the same trends observed in cilia.
2020
Motile cilia; Multiciliated cell; Synchronization; Animals; Brain; Chlamydomonas; Cilia; Hydrodynamics; Mammals; Models, Biological
01 Pubblicazione su rivista::01a Articolo in rivista
Entrainment of mammalian motile cilia in the brain with hydrodynamic forces / Pellicciotta, N.; Hamilton, E.; Kotar, J.; Faucourt, M.; Delgehyr, N.; Spassky, N.; Cicuta, P.. - In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. - ISSN 0027-8424. - 117:15(2020), pp. 8315-8325. [10.1073/pnas.1910065117]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1560490
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