The chemotactic and random mobility functions of twelve selectively IgA-deficient patients were evaluated by a method using agarose gel. A severe polymorphonuclear cellular chemotactic defect was found in ten out of twelve patients, but only five of them also showed a marked associated impairment of random locomotory function. Futhermore, in one subject, levamisole therapy resulted in a dramatic improvement of both chemotactic and random mobility functions. These results are discussed in the paper with respect to the possible pathogenetic implications.
Neutrophil chemotaxis defect in IgA deficiency evaluated by migration agarose method / D'Amelio, Raffaele; S., Lemoli; P., Rossi; F., Aiuti. - In: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. - ISSN 0300-9475. - 11:5(1980), pp. 471-477.
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Titolo: | Neutrophil chemotaxis defect in IgA deficiency evaluated by migration agarose method | |
Autori: | ||
Data di pubblicazione: | 1980 | |
Rivista: | ||
Citazione: | Neutrophil chemotaxis defect in IgA deficiency evaluated by migration agarose method / D'Amelio, Raffaele; S., Lemoli; P., Rossi; F., Aiuti. - In: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. - ISSN 0300-9475. - 11:5(1980), pp. 471-477. | |
Handle: | http://hdl.handle.net/11573/15600 | |
Appartiene alla tipologia: | 01a Articolo in rivista |